Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada.
The Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada.
J Leukoc Biol. 2019 Jun;105(6):1285-1296. doi: 10.1002/JLB.MR0718-298R. Epub 2019 Mar 1.
It is now evident that NK cells kill bacteria, fungi, and parasites in addition to tumor and virus-infected cells. In addition to a number of recent publications that have identified the receptors and ligands, and mechanisms of cytotoxicity, new insights are reflected in the reports from researchers all over the world at the 17th Meeting of the Society for Natural Immunity held in San Antonio, TX, USA from May 28 through June 1, 2018. We will provide an overview of the field and discuss how the presentations at the meeting might shape our knowledge and future directions in the field.
现在已经很明显了,NK 细胞除了能够杀死肿瘤和病毒感染的细胞外,还能杀死细菌、真菌和寄生虫。除了最近的一些出版物已经确定了受体和配体以及细胞毒性的机制外,在美国德克萨斯州圣安东尼奥市举行的第 17 届自然免疫学会会议上,来自世界各地的研究人员的报告也反映了新的见解。我们将对该领域进行概述,并讨论会议上的报告将如何影响我们在该领域的知识和未来方向。