Lee Yun Kyong, Haam Ji-Hee, Suh Eunkyung, Cho Sung Hoon, Kim Young-Sang
Chaum Life Center, CHA University, Seoul 06062, Korea.
TS Bio, Seoul 08389, Korea.
J Clin Med. 2022 May 26;11(11):3014. doi: 10.3390/jcm11113014.
Polyvalent mechanical bacterial lysate (PMBL) is used for the treatment and prevention of recurrent respiratory tract infections. Although PMBL is an immunostimulant, it remains unknown whether treatment with PMBL influences natural killer cell activity (NKA). Hence, this case-control study compared the changes in IFN-γ levels (surrogate index for NKA) following PMBL treatment or time passing between the PMBL-treated group and controls. The treatment group included adults who had a PMBL prescription for three months against recurrent respiratory tract infection from an outpatient clinic, while the control group had healthy adults visiting the health promotion center for periodic health check-ups. The control group (N = 506) showed no change in IFN-γ levels, while the treatment group (N = 301) showed a significant increase in mean from 462.8 to 749.3 pg/mL after PMBL treatment. In the subgroup with IFN-γ <500 pg/mL, IFN-γ levels significantly increased in both groups. However, the change in the treatment group (287 ± 822 pg/mL) was greater than that in the control group (58 ± 809 pg/mL), and the interaction between the visit and case/control was significant (p = 0.030) in a generalized estimating equation model. In conclusion, NKA increased in the subjects with recurrent respiratory tract infections with PMBL treatment.
多价机械性细菌裂解物（PMBL）用于治疗和预防反复呼吸道感染。尽管PMBL是一种免疫刺激剂，但PMBL治疗是否会影响自然杀伤细胞活性（NKA）仍不清楚。因此，本病例对照研究比较了PMBL治疗组和对照组在PMBL治疗后或随着时间推移IFN-γ水平（NKA的替代指标）的变化。治疗组包括因反复呼吸道感染从门诊获得为期三个月PMBL处方的成年人，而对照组为到健康促进中心进行定期健康检查的健康成年人。对照组（N = 506）的IFN-γ水平无变化，而治疗组（N = 301）在PMBL治疗后平均水平从462.8 pg/mL显著增加至749.3 pg/mL。在IFN-γ<500 pg/mL的亚组中，两组的IFN-γ水平均显著升高。然而，治疗组的变化（287±822 pg/mL）大于对照组（58±809 pg/mL），在广义估计方程模型中，就诊与病例/对照之间的交互作用具有显著性（p = 0.030）。总之，接受PMBL治疗的反复呼吸道感染患者的NKA增加。
