Doehring E, Poggensee U, Feldmeier H
Am J Trop Med Hyg. 1986 Mar;35(2):323-9. doi: 10.4269/ajtmh.1986.35.323.
In order to examine the effect of metrifonate, 156 patients with mixed Schistosoma haematobium and mansoni infection were randomly divided into three groups and treated with metrifonate (twice 10 mg/kg body weight), oxamniquine (60 mg/kg) and praziquantel (40 mg/kg), respectively. The output of S. haematobium and S. mansoni ova were quantitatively assessed in urine and stool. Application of metrifonate resulted in a similar reduction of S. haematobium and S. mansoni eggs in the urine, whereas no effect on egg excretion was observed in the stool irrespective of the parasite species. In contrast, oxamniquine influenced the output of S. mansoni ova in stool and urine, but showed no effect on S. haematobium egg excretion. praziquantel was equally effective against both parasite species. The chemotherapeutic effects were not of transient nature since the number of ova of both parasite species remained unchanged five months after treatment. The results clearly indicate that metrifonate acted exclusively on adult worms located in the perivesical plexus irrespective of the parasite species.
为研究敌百虫的疗效，将156例埃及血吸虫和曼氏血吸虫混合感染患者随机分为三组，分别接受敌百虫（两次，10mg/kg体重）、奥沙尼喹（60mg/kg）和吡喹酮（40mg/kg）治疗。对尿液和粪便中埃及血吸虫和曼氏血吸虫卵的排出量进行了定量评估。应用敌百虫后，尿液中埃及血吸虫和曼氏血吸虫卵的减少情况相似，而无论寄生虫种类如何，粪便中虫卵排出均未受影响。相比之下，奥沙尼喹影响粪便和尿液中曼氏血吸虫卵的排出量，但对埃及血吸虫卵的排出无影响。吡喹酮对两种寄生虫均同样有效。化疗效果并非短暂性的，因为治疗五个月后两种寄生虫的虫卵数量均未改变。结果清楚地表明，敌百虫仅作用于位于膀胱周围丛的成虫，而与寄生虫种类无关。
