Feldmeier H, Doehring E, Daffala A A, Omer A H, Dietrich M
Am J Trop Med Hyg. 1982 Nov;31(6):1188-94. doi: 10.4269/ajtmh.1982.31.1188.
Patients with schistosomiasis mansoni and schistosomiasis haematobium from the Gezira area of the Sudan were investigated for the simultaneous presence of Schistosoma mansoni and S. haematobium eggs in urine. Before treatment, 28 or 34 mixed-infection patients constantly excreted eggs of S. mansoni in the urine; however, the concentration was only 1.7% that of S. haematobium eggs. Patients were given two doses of metrifonate (10 mg/kg body weight) 2 weeks apart in order to compare the effect of the organophosphorous compound on the two parasite species. Each dose of metrifonate was followed by a significant decrease in egg output in urine (P less than 0.01). The egg reduction was similar for both parasite species, and was almost 99% after the second treatment. Before treatment was started, a positive correlation existed between the numbers of S. haematobium and S. mansoni eggs excreted in urine (r = 0.75, P less than 0.001), and this correlation did not change after the first or the second dose of metrifonate. After treatment, in 6 of 37 patients S. haematobium eggs and in 8 of 28 patients S. mansoni eggs were not, or were only slightly, reduced. When chemotherapeutic failure of metrifonate against S. haematobium or S. mansoni occurred, it was quantitatively similar for both parasite species.
对苏丹杰济拉地区曼氏血吸虫病和埃及血吸虫病患者进行了尿液中同时存在曼氏血吸虫和埃及血吸虫虫卵的调查。治疗前，28名或34名混合感染患者持续在尿液中排出曼氏血吸虫虫卵；然而，其浓度仅为埃及血吸虫虫卵浓度的1.7%。为比较有机磷化合物对这两种寄生虫的作用，患者每隔2周接受两剂敌百虫（10mg/kg体重）治疗。每次服用敌百虫后，尿液中虫卵排出量均显著下降（P<0.01）。两种寄生虫的虫卵减少情况相似，第二次治疗后几乎减少了99%。在开始治疗前，尿液中排出的埃及血吸虫和曼氏血吸虫虫卵数量之间存在正相关（r = 0.75，P<0.001），在第一次或第二次服用敌百虫后，这种相关性没有改变。治疗后，37名患者中有6名埃及血吸虫虫卵以及28名患者中有8名曼氏血吸虫虫卵未减少或仅略有减少。当敌百虫对埃及血吸虫或曼氏血吸虫化疗失败时，两种寄生虫在数量上的情况相似。
