Department of Neurology, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.
Cardiovascular Center, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Republic of Korea.
PLoS One. 2019 Mar 1;14(3):e0208189. doi: 10.1371/journal.pone.0208189. eCollection 2019.
Physical inactivity is an important but often neglected risk factor for various cardiovascular diseases. We hypothesized that physical inactivity might have deleterious effects on metabolic health in obese and non-obese subjects.
We evaluated the effect of physical activity on the cardiometabolic profiles of a nationwide cohort of non-obese and obese individuals who did not have overt cardiovascular diseases. A total of 3,830 study subjects were divided into two groups based on their body mass index (BMI). Within each BMI group, participants were divided according to their physical activity level. To ascertain their cardiometabolic profiles, we collected data regarding the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, high-density lipoprotein (HDL)-cholesterol level, systolic blood pressure, heart rate, and high-sensitivity C-reactive protein (hsCRP) level.
Physically inactive subjects demonstrated markedly elevated HOMA-IR index and heart rates in each BMI category, even after adjustments for baseline covariates. They also tended to have worse profiles for HDL-cholesterol, systolic blood pressure, and hsCRP levels. A significant elevation in cardiometabolic risk was noted across the four physical activity/obesity groups (p<0.05). HOMA-IR index was largely affected by obesity, but within each BMI category, physical inactivity independently elevated the risk for worsening insulin resistance. In addition, physical inactivity significantly increased the risk of elevated heart rate in both non-obese and obese individuals. Notably, the detrimental effect of physical activity on heart rate was not modified by obesity.
Physical activity was associated with favorable cardiometabolic risk profiles with regard to insulin resistance status and heart rate level in both BMI groups. Our results suggest that increasing physical activity could be a helpful strategy for improving the cardiometabolic health in the Korean population, regardless of obesity status.
身体活动不足是各种心血管疾病的一个重要但常被忽视的危险因素。我们假设身体活动不足可能对肥胖和非肥胖受试者的代谢健康产生有害影响。
我们评估了身体活动对无明显心血管疾病的全国性肥胖和非肥胖人群的心脏代谢特征的影响。共有 3830 名研究对象根据体重指数（BMI）分为两组。在每个 BMI 组内，根据身体活动水平将参与者分为不同组别。为了确定他们的心脏代谢特征，我们收集了有关稳态模型评估估计的胰岛素抵抗（HOMA-IR）指数、高密度脂蛋白（HDL）-胆固醇水平、收缩压、心率和高敏 C 反应蛋白（hsCRP）水平的数据。
即使在调整了基线协变量后，非活跃组的 HOMA-IR 指数和心率在每个 BMI 类别中都明显升高。他们的 HDL-胆固醇、收缩压和 hsCRP 水平也较差。在四个身体活动/肥胖组中，观察到心脏代谢风险显著升高（p<0.05）。HOMA-IR 指数主要受肥胖影响，但在每个 BMI 类别中，不活动独立增加了胰岛素抵抗恶化的风险。此外，不活动显著增加了非肥胖和肥胖个体的心率升高风险。值得注意的是，肥胖并没有改变身体活动对心率的不利影响。
身体活动与两种 BMI 组的胰岛素抵抗状态和心率水平的心脏代谢风险特征相关。我们的结果表明，增加身体活动可能是改善韩国人群心脏代谢健康的有益策略，无论肥胖状况如何。
