Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan 33302, Taiwan.
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan 33302, Taiwan.
Nutrients. 2019 Feb 28;11(3):530. doi: 10.3390/nu11030530.
About 40% of the world's population is overweight or obese and exist at risk of developing type 2 diabetes mellitus (T2D). Obesity is a leading pathogenic factor for developing insulin resistance (IR). It is well established that IR and a progressive decline in functional β-cell mass are hallmarks of developing T2D. In order to mitigate the global prevalence of T2D, we must carefully select the appropriate animal models to explore the cellular and molecular mechanisms of T2D, and to optimize novel therapeutics for their safe use in humans. Flavonoids, a group of polyphenols, have drawn great interest for their various health benefits, and have been identified in naturally occurring anti-diabetic compounds. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might prove helpful in preventing T2D. In this review, we discuss the currently available rodent animal models of T2D and analyze the advantages, the limitations of each T2D model, and highlight the potential anti-diabetic effects of flavonoids as well as the mechanisms of their actions.
约 40%的世界人口超重或肥胖，存在患 2 型糖尿病（T2D）的风险。肥胖是导致胰岛素抵抗（IR）的主要致病因素。众所周知，IR 和功能性β细胞数量的逐渐减少是 T2D 发病的标志。为了减轻 T2D 的全球流行，我们必须仔细选择合适的动物模型来探索 T2D 的细胞和分子机制，并优化新型疗法以确保其在人类中的安全使用。类黄酮作为一组多酚，因其多种健康益处而备受关注，并已在天然存在的抗糖尿病化合物中得到鉴定。许多临床和动物研究的结果表明，饮食中摄入类黄酮可能有助于预防 T2D。在这篇综述中，我们讨论了目前可用的 T2D 啮齿动物动物模型，并分析了每种 T2D 模型的优点和局限性，强调了类黄酮的潜在抗糖尿病作用及其作用机制。
