Ahmed Ayman, Elduma Adel, Magboul Babiker, Higazi Tarig, Ali Yousif
Institute of Endemic Diseases, University of Khartoum, Khartoum 11111, Sudan.
Department of Vector Biology, Liverpool School of Tropical Medicine (LSTM), Liverpool L3 5QA, UK.
Trop Med Infect Dis. 2019 Mar 1;4(1):43. doi: 10.3390/tropicalmed4010043.
Dengue virus (DENV) is an arthropod-borne virus (arbovirus) transmitted by the mosquitoes, mainly . Dengue fever is a rapidly growing disease with expanding geographical distribution worldwide. We investigated a high number of non-malaria febrile cases reported to health clinics in refugee camps in the five states of Darfur between August 2015 and March 2016. The clinical presentation of cases and case definition criteria suggested involvement of one or more arboviral hemorrhagic fevers. Out of 560 suspected cases, we collected and analyzed 204 blood samples and serologically positive samples were confirmed by PCR. We identified 32 (15.7%) dengue viral infections, six West Nile virus infections, and three Crimean⁻Congo viral infections. Dengue infections were found in four out of the five Darfur states. We reported the first dengue fever outbreak in the Darfur region. Our results highlight the need for public health education and further molecular, phylogenetic, and entomological investigations for a better understanding of the disease transmission and the associated risk factors in the region.
登革病毒（DENV）是一种主要由蚊子传播的节肢动物传播病毒（虫媒病毒）。登革热是一种在全球地理分布不断扩大且迅速蔓延的疾病。我们对2015年8月至2016年3月期间达尔富尔五个州难民营向卫生诊所报告的大量非疟发热病例进行了调查。病例的临床表现和病例定义标准提示一种或多种虫媒病毒出血热。在560例疑似病例中，我们采集并分析了204份血样，血清学阳性样本通过聚合酶链反应（PCR）得到确认。我们鉴定出32例（15.7%）登革病毒感染、6例西尼罗河病毒感染和3例克里米亚-刚果病毒感染。在达尔富尔五个州中的四个州发现了登革热感染病例。我们报告了达尔富尔地区的首例登革热疫情。我们的结果凸显了开展公共卫生教育以及进一步进行分子、系统发育和昆虫学调查的必要性，以便更好地了解该地区的疾病传播情况及相关风险因素。
