Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human Infections and Immunity and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
National Public Health Laboratory, Sudan Federal Ministry of Health, Khartoum, Sudan.
Int J Infect Dis. 2021 Jul;108:513-516. doi: 10.1016/j.ijid.2021.05.052. Epub 2021 May 24.
This study aimed to investigate an outbreak of a non-malaria, undifferentiated febrile illness, among internally displaced persons (IDPs) living in humanitarian camps in North Darfur, Sudan, in 2019.
An investigation team was deployed to North Darfur to identify suspected cases and collect blood samples, and clinical and demographical data. Blood samples were examined microscopically for Plasmodium spp and tested for dengue (DENV) and yellow fever viruses by reverse transcriptase-quantitative polymerase chain reaction.
Between September 7 and December 18, 2019, we clinically identified 18 (24%), 41 (54%), and 17 (22%) cases of dengue fever, dengue with warning signs, and severe dengue, respectively. Blood samples were collected from 22% of patients, and 47% of these tested positive for DENV-1 RNA. We confirmed 32 malaria cases with 5 co-infections with DENV. This outbreak of dengue was the first among IDPs in the humanitarian camps.
Our findings indicate that dengue has become endemic or that there has been a new introduction. Further epidemiological, entomological, and phylogenetic studies are needed to understand disease transmission in the area. An early warning and response system and an effective health policy are crucial for preventing and controlling arboviruses in Sudan.
本研究旨在调查 2019 年在苏丹北达尔富尔的难民营中，居住的国内流离失所者（IDPs）中爆发的一种非疟疾、未分化的发热疾病。
一个调查组被部署到北达尔富尔，以确定疑似病例并采集血样，以及临床和人口统计学数据。血样进行显微镜检查以检测疟原虫属，并通过逆转录定量聚合酶链反应检测登革热（DENV）和黄热病病毒。
2019 年 9 月 7 日至 12 月 18 日，我们分别临床诊断出登革热、登革热伴警示征和重症登革热各 18（24%）、41（54%）和 17（22%）例。采集了 22%的患者的血样，其中 47%的血样检测出 DENV-1 RNA 阳性。我们确诊了 32 例疟疾病例，其中 5 例与 DENV 合并感染。这是难民营中 IDPs 首次爆发登革热。
我们的发现表明，登革热已成为地方性疾病或新的传入疾病。需要进一步进行流行病学、昆虫学和系统发育学研究，以了解该地区的疾病传播。预警和应对系统以及有效的卫生政策对于在苏丹预防和控制虫媒病毒至关重要。
