Efendiev A M, Pomoĭnetskiĭ V D, Kubatiev A A
Biull Eksp Biol Med. 1986 Mar;101(3):302-4.
Prostaglandin (PG)-synthestase activity was studied in the cortical, medullary and papillary kidney layers in young rats subjected to prolonged administration of polyene antibiotics (amphotericin B, levorin and nystatin). This activity was markedly increased during the first few hours after the administration of amphotericin B. At later terms a pronounced decline in the enzyme activity was observed. The changes were most prominent in the medullary and papillary layers. The other two antibiotics were less potent. The experimental results have shown that amphotericin B had maximal effect on renal PG-synthetase activity, while the sodium salt of nystatin was least effective.
研究了长期给予多烯抗生素（两性霉素B、制霉菌素和制霉素）的幼鼠肾皮质、髓质和乳头层中的前列腺素（PG）合成酶活性。给予两性霉素B后的最初几个小时内，该活性显著增加。在后期观察到酶活性明显下降。这些变化在髓质和乳头层最为显著。另外两种抗生素的作用较小。实验结果表明，两性霉素B对肾PG合成酶活性的影响最大，而制霉菌素钠盐的效果最差。
