Efendiev A M, Pomoĭnetskiĭ V D, Kubatiev A A, Gonobobleva T N
Vopr Med Khim. 1986 Jul-Aug;32(4):102-6.
Effect of polyenic antibiotics amphotericin B, levorin, nystatin on activity of prostaglandin metabolizing enzymes was studied in cortex, medullar and papillary layers of young rat kidneys. Amphotericin B was shown to exhibit the maximal effect on the enzymatic activity. Distinct "impairing" action of the antibiotics, especially of amphotericin B, was found in medullar and papillary layers of kidney at the end of the experiment carried out within 8 days.
研究了多烯抗生素两性霉素B、利弗菌素、制霉菌素对幼鼠肾脏皮质、髓质和乳头层前列腺素代谢酶活性的影响。结果表明，两性霉素B对酶活性的影响最大。在为期8天的实验结束时，发现这些抗生素，尤其是两性霉素B，在肾脏的髓质和乳头层具有明显的“损害”作用。
