• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.前列腺素内过氧化物、血栓素A2和二磷酸腺苷在人和大鼠胶原诱导聚集反应中的作用。
Br J Pharmacol. 1986 Jan;87(1):109-15. doi: 10.1111/j.1476-5381.1986.tb10162.x.
2
Prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation of rabbit platelets.前列腺素内过氧化物、血栓素A2和二磷酸腺苷在胶原诱导的兔血小板聚集中的作用
Br J Pharmacol. 1982 Apr;75(4):623-31. doi: 10.1111/j.1476-5381.1982.tb09183.x.
3
Pathways responsible for platelet hypersensitivity in rats with diabetes. I. Streptozocin-induced diabetes.糖尿病大鼠血小板超敏反应的相关通路。I. 链脲佐菌素诱导的糖尿病。
J Lab Clin Med. 1986 Feb;107(2):148-53.
4
Arachidonate induced aggregation of rat platelets may not require prostaglandin endoperoxides or thromboxane A2.花生四烯酸盐诱导的大鼠血小板聚集可能不需要前列腺素内过氧化物或血栓素A2。
Thromb Res. 1983 May 1;30(3):289-96. doi: 10.1016/0049-3848(83)90082-8.
5
Pathways responsible for platelet hypersensitivity in rats with diabetes. II. Spontaneous diabetes in BB Wistar rats.糖尿病大鼠血小板超敏反应的相关通路。II. BB 威斯塔大鼠的自发性糖尿病。
J Lab Clin Med. 1986 Feb;107(2):154-8.
6
Further evidence against the validity of using an ADP-removing enzyme system (CP/CPK) for demonstrating the role of secreted ADP in platelet activation.进一步证明了使用ADP去除酶系统（CP/CPK）来证明分泌的ADP在血小板激活中的作用是无效的。
Thromb Res. 1983 Apr 1;30(1):19-26. doi: 10.1016/0049-3848(83)90393-6.
7
In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production.匹可他胺对人血小板聚集、释放反应及血栓素B2生成的体外作用。
Thromb Res. 1991 Jun 15;62(6):717-24. doi: 10.1016/0049-3848(91)90375-7.
8
Investigation on a selective non-prostanoic thromboxane antagonist, BM 13.177, in human platelets.对一种选择性非前列腺素类血栓素拮抗剂BM 13.177在人血小板中的研究。
Thromb Res. 1984 Feb 1;33(3):277-88. doi: 10.1016/0049-3848(84)90163-4.
9
High concentrations of arachidonic acid induce platelet aggregation and serotonin release independent of prostaglandin endoperoxides and thromboxane A2.高浓度花生四烯酸可诱导血小板聚集和5-羟色胺释放，且不依赖于前列腺素内过氧化物和血栓素A2。
Biochim Biophys Acta. 1985 Sep 6;841(3):283-91. doi: 10.1016/0304-4165(85)90070-4.
10
A comparative study of the involvement of the prostaglandin H2/thromboxane A2 pathway in intravascular platelet aggregation in guinea-pigs and rats.豚鼠和大鼠体内前列腺素H2/血栓素A2途径参与血管内血小板聚集的比较研究。
Br J Pharmacol. 1985 Feb;84(2):425-30. doi: 10.1111/j.1476-5381.1985.tb12926.x.

引用本文的文献

1
Antithrombotic Potential of Tormentil Extract in Animal Models.委陵菜提取物在动物模型中的抗血栓形成潜力。
Front Pharmacol. 2017 Aug 15;8:534. doi: 10.3389/fphar.2017.00534. eCollection 2017.
2
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties.CS-747是一种具有血小板ADP受体拮抗剂特性的新型抗血小板药物，其体内药理学特征。
Br J Pharmacol. 2000 Apr;129(7):1439-46. doi: 10.1038/sj.bjp.0703237.
3
Aggretin, a novel platelet-aggregation inducer from snake (Calloselasma rhodostoma) venom, activates phospholipase C by acting as a glycoprotein Ia/IIa agonist.凝集素是一种从红口蝮蛇毒液中提取的新型血小板聚集诱导剂，它通过作为糖蛋白Ia/IIa激动剂来激活磷脂酶C。
Biochem J. 1995 Aug 1;309 ( Pt 3)(Pt 3):1021-7. doi: 10.1042/bj3091021.
4
Aggregation and/or oxygenated products of arachidonic acid are not required for collagen-induced deacylation of phosphatidylcholine in human platelets.花生四烯酸的聚集和/或氧化产物并非人血小板中胶原蛋白诱导的磷脂酰胆碱脱酰基作用所必需。
Biochem J. 1989 Oct 1;263(1):143-8. doi: 10.1042/bj2630143.

本文引用的文献

1
RELEASE OF A PLATELET-AGGREGATING SUBSTANCE (ADENOSINE DIPHOSPHATE) FROM RABBIT BLOOD PLATELETS INDUCED BY SALINE "EXTRACT" OF TENDONS.肌腱盐水“提取物”诱导兔血小板释放血小板聚集物质（二磷酸腺苷）
Thromb Diath Haemorrh. 1963 Jul 15;143:264-78.
2
Effect of inhibitors of the arachidonate pathway on the release of granule contents from rabbit platelets adherent to collagen.花生四烯酸途径抑制剂对黏附于胶原蛋白的兔血小板颗粒内容物释放的影响。
Lab Invest. 1980 Jan;42(1):28-34.
3
Stimulated platelet aggregation, thromboxane B2 formation and platelet sensitivity to prostacyclin - a critical evaluation.刺激血小板聚集、血栓素B2形成及血小板对前列环素的敏感性——一项批判性评估
Thromb Haemost. 1981 Jun 30;45(3):204-7.
4
Prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation of rabbit platelets.前列腺素内过氧化物、血栓素A2和二磷酸腺苷在胶原诱导的兔血小板聚集中的作用
Br J Pharmacol. 1982 Apr;75(4):623-31. doi: 10.1111/j.1476-5381.1982.tb09183.x.
5
Bradykinin-stimulated prostaglandin E2 production by endothelial cells and its modulation by antiinflammatory compounds.缓激肽刺激内皮细胞产生前列腺素E2及其受抗炎化合物的调节作用。
Inflammation. 1981 Dec;5(4):363-78. doi: 10.1007/BF00911100.
6
The interrelationship between thromboxane biosynthesis, aggregation and 5-hydroxytryptamine secretion in human platelets in vitro.体外人血小板中血栓素生物合成、聚集与5-羟色胺分泌之间的相互关系。
Thromb Haemost. 1980 Feb 29;43(1):38-40.
7
Prolongation of rat tail bleeding time caused by oral doses of a thromboxane synthetase inhibitor which have little effect on platelet aggregation.口服剂量的血栓素合成酶抑制剂可延长大鼠尾部出血时间，而该抑制剂对血小板聚集几乎没有影响。
Thromb Haemost. 1982 Feb 26;47(1):46-9.
8
Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways.人类血小板活化的调节——环氧合酶和环磷酸腺苷依赖性途径的分析
Biochem Pharmacol. 1984 Oct 1;33(19):3025-35. doi: 10.1016/0006-2952(84)90604-x.
9
Radioimmunoassay of prostaglandin F-2-alpha in peripheral venous plasma from men and women.男性和女性外周静脉血浆中前列腺素F-2-α的放射免疫测定
Prostaglandins. 1974 Mar 25;5(6):531-42. doi: 10.1016/s0090-6980(74)80028-6.
10
Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction.前列腺素生物合成中一种中间体的形成及其与血小板释放反应的关联。
J Clin Invest. 1974 May;53(5):1468-72. doi: 10.1172/JCI107695.

前列腺素内过氧化物、血栓素A2和二磷酸腺苷在人和大鼠胶原诱导聚集反应中的作用。

The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.

作者信息

Emms H, Lewis G P

出版信息

Br J Pharmacol. 1986 Jan;87(1):109-15. doi: 10.1111/j.1476-5381.1986.tb10162.x.

DOI:10.1111/j.1476-5381.1986.tb10162.x
PMID:3082399
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1916885/
Abstract

The effects of aspirin, carboxyheptylimidazole (CHI) and creatine phosphate/creatine phosphokinase (CP/CPK) on platelet aggregation and thromboxane B2 (TxB2) formation induced by collagen have been examined in vitro. Platelets from two species, man and the rat, have been used. In man, aspirin and CHI abolished TxB2 production but only partially inhibited aggregation. CP/CPK partially inhibited aggregation and TxB2 formation. In the rat, aspirin and CHI abolished TxB2 formation but had no effect on aggregation. CP/CPK completely inhibited aggregation and partially inhibited TxB2 generation. In man, collagen-induced aggregation is largely dependent on ADP and to a lesser extent on arachidonate metabolites whereas, in the rat, ADP alone mediates aggregation induced by this agonist. The results with CP/CPK suggest that TxB2 formation is dependent either on the prior release of platelet ADP or on aggregation itself rather than being responsible for the aggregation response.

摘要

已在体外研究了阿司匹林、羧基庚基咪唑（CHI）以及磷酸肌酸/肌酸磷酸激酶（CP/CPK）对胶原诱导的血小板聚集和血栓素B2（TxB2）形成的影响。使用了两种物种（人类和大鼠）的血小板。在人类中，阿司匹林和CHI可消除TxB2的产生，但仅部分抑制聚集。CP/CPK部分抑制聚集和TxB2的形成。在大鼠中，阿司匹林和CHI可消除TxB2的形成，但对聚集无影响。CP/CPK完全抑制聚集并部分抑制TxB2的产生。在人类中，胶原诱导的聚集很大程度上依赖于ADP，在较小程度上依赖于花生四烯酸代谢产物，而在大鼠中，仅ADP介导该激动剂诱导的聚集。CP/CPK的研究结果表明，TxB2的形成要么依赖于血小板ADP的预先释放，要么依赖于聚集本身，而不是聚集反应的原因。