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阿莫地喹可引起粒细胞缺乏症和肝损伤。

Amodiaquine induced agranulocytosis and liver damage.

作者信息

Neftel K A, Woodtly W, Schmid M, Frick P G, Fehr J

出版信息

Br Med J (Clin Res Ed). 1986 Mar 15;292(6522):721-3. doi: 10.1136/bmj.292.6522.721.

DOI:10.1136/bmj.292.6522.721
PMID:3082410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1339778/
Abstract

Seven cases of agranulocytosis and two of liver damage that were probably due to amodiaquine treatment were studied. In five cases agranulocytosis was combined with liver damage, and in one case of primary liver damage moderate neutropenia was present. Three patients died. High total doses or prolonged duration of treatment, or both, appear to favour the occurrence of these reactions. The clustering of five of the seven cases of agranulocytosis within six months in one medical centre indicates that the risk to benefit ratio of amodiaquine for malaria prophylaxis should be re-evaluated.

摘要

对7例可能由阿莫地喹治疗引起的粒细胞缺乏症和2例肝损伤病例进行了研究。5例粒细胞缺乏症合并肝损伤，1例原发性肝损伤患者存在中度中性粒细胞减少。3例患者死亡。高总剂量或延长治疗时间，或两者兼而有之，似乎有利于这些反应的发生。7例粒细胞缺乏症中有5例在一个医疗中心6个月内聚集出现，这表明应重新评估阿莫地喹用于疟疾预防的风险效益比。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f4b/1339778/7a32b643d6c8/bmjcred00225-0015-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f4b/1339778/cac98742175c/bmjcred00225-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f4b/1339778/7a32b643d6c8/bmjcred00225-0015-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f4b/1339778/cac98742175c/bmjcred00225-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f4b/1339778/7a32b643d6c8/bmjcred00225-0015-a.jpg

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Amodiaquine induced agranulocytosis and liver damage.阿莫地喹可引起粒细胞缺乏症和肝损伤。
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本文引用的文献

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2
The effect of amodiaquin (camoquin) on the course of rheumatoid arthritis.氨酚喹（卡莫喹）对类风湿性关节炎病程的影响。
Arthritis Rheum. 1959 Oct;2:396-402. doi: 10.1002/1529-0131(195910)2:5<396::aid-art1780020504>3.0.co;2-t.
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BENIGN POSTOPERATIVE INTRAHEPATIC CHOLESTASIS.
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Molecules. 2024 Nov 14;29(22):5357. doi: 10.3390/molecules29225357.
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Novel Therapeutics for Malaria.疟疾的新型疗法
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Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies.心血管浓度-效应关系的阿莫地喹及其代谢产物去乙基阿莫地喹：临床和临床前研究。
Br J Clin Pharmacol. 2023 Mar;89(3):1176-1186. doi: 10.1111/bcp.15569. Epub 2022 Nov 8.
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Biochem Pharmacol. 2022 Jul;201:115080. doi: 10.1016/j.bcp.2022.115080. Epub 2022 May 10.
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Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges.特发性药物性肝损伤：机制和临床挑战。
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Malar J. 2021 Feb 15;20(1):90. doi: 10.1186/s12936-021-03620-6.
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