阿莫地喹预防疟疾时诱发的粒细胞缺乏症：针对粒细胞的阿莫地喹诱导细胞毒性抗体的证实
[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes].
作者信息
Schulthess H K, von Felten A, Gmür J, Neftel K
出版信息
Schweiz Med Wochenschr. 1983 Dec 17;113(50):1912-3.
PMID:6665534
Abstract
A patient is presented who developed agranulocytosis while taking amodiaquine for suppressive therapy of malaria. An amodiaquine-dependent granulocytotoxic antibody could be demonstrated in the patient's serum on day 1 after stopping amodiaquine medication. Granulocyte transfusion was ineffective on days 6 and 7, possibly due to the slow elimination of the drug.
摘要
报告了一名患者，该患者在服用阿莫地喹进行疟疾抑制治疗时发生了粒细胞缺乏症。在停用阿莫地喹药物后的第1天，在患者血清中检测到了一种依赖于阿莫地喹的粒细胞毒性抗体。在第6天和第7天，粒细胞输注无效，这可能是由于药物清除缓慢所致。
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