INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; Dipartimento di Fisica e Astronomia, Universitá degli Studi di Catania, Via S. Sofia 64, 95123 Catania, Italy.
INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; National Physical Laboratory, Acoustic and Ionizing Radiation Division, Teddington TW11 0LW, Middlesex, UK.
Phys Med. 2019 Feb;58:72-80. doi: 10.1016/j.ejmp.2019.01.018. Epub 2019 Feb 5.
The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams.
The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data.
The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
使用 Geant4 蒙特卡罗模拟工具包来复制用单色和临床质子束照射三种不同癌细胞系所测量的放射生物学参数。
采用专用的开源 Geant4 应用程序对辐照实验装置进行了全面模拟。通过将 Geant4 模拟与两个分析放射生物学模型相结合来计算细胞存活分数：一个基于 LEM（局部效应模型）方法，另一个基于半经验参数化。评估结果并与实验数据进行比较。
结果表明 Geant4 有能力复制不同细胞系的放射生物学量。
