Groenendijk Celebrity F, Rovituso Marta, Lathouwers Danny, Brown Jeremy M C
Radiation Science & Technology, Delft University of Technology, Delft, The Netherlands.
Research and Development, Holland Proton Therapy Centre, Delft, The Netherlands.
Phys Med. 2023 Aug;112:102643. doi: 10.1016/j.ejmp.2023.102643. Epub 2023 Jul 30.
A Geant4 based simulation platform of the Holland Proton Therapy Centre (HollandPTC, Netherlands) R&D beamline (G4HPTC-R&D) was developed to enable the planning, optimisation and advanced dosimetry for radiobiological studies. It implemented a six parameter non-symmetrical Gaussian pencil beam surrogate model to simulate the R&D beamline in both a pencil beam and passively scattered field configuration. Three different experimental proton datasets (70 MeV, 150 MeV, and 240 MeV) of the pencil beam envelope evolution in free air and depth-dose profiles in water were used to develop a set of individual parameter surrogate functions to enable the modelling of the non-symmetrical Gaussian pencil beam properties with only the ProBeam isochronous cyclotron mean extraction proton energy as input. This refined beam model was then benchmarked with respect to three independent experimental datasets of the R&D beamline operating in both a pencil beam configuration at 120 and 200 MeV, and passively scattered field configuration at 150 MeV. It was shown that the G4HPTC-R&D simulation platform can reproduce the pencil beam envelope evolution in free air and depth-dose profiles to within an accuracy on the order of ±5% for all tested energies, and that it was able to reproduce the 150 MeV passively scattered field to the specifications need for clinical and radiobiological applications.
开发了一个基于Geant4的荷兰质子治疗中心（荷兰PTC，荷兰）研发束线模拟平台（G4HPTC-R&D），以实现放射生物学研究的治疗计划、优化和先进剂量测定。它采用了一个六参数非对称高斯笔形束替代模型，以在笔形束和被动散射场配置中模拟研发束线。使用了三种不同的实验质子数据集（70 MeV、150 MeV和240 MeV），分别是自由空气中笔形束包络线的演变以及水中深度剂量分布，来开发一组单独的参数替代函数，以便仅以ProBeam等时回旋加速器的平均引出质子能量作为输入，对非对称高斯笔形束特性进行建模。然后，针对研发束线的三个独立实验数据集对这个改进的束模型进行了基准测试，这些数据集分别是在120 MeV和200 MeV的笔形束配置以及150 MeV的被动散射场配置下运行的。结果表明，G4HPTC-R&D模拟平台能够将自由空气中笔形束包络线的演变和深度剂量分布再现到所有测试能量下精度约为±5%的范围内，并且能够将150 MeV的被动散射场再现到临床和放射生物学应用所需的规格。
