老年大鼠在亚最大运动期间肋间肌血流增加。
Intercostal muscle blood flow is elevated in old rats during submaximal exercise.
机构信息
Department of Kinesiology, Kansas State University, Manhattan, KS, 66506, United States; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55901, United States.
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, 66506, United States.
出版信息
Respir Physiol Neurobiol. 2019 May;263:26-30. doi: 10.1016/j.resp.2019.02.003. Epub 2019 Feb 27.
BACKGROUND
Respiratory muscle blood flows (BF) increase substantially during exercise in younger adult rats. As aging is associated with altered pulmonary function, we hypothesized that old rats will have greater intercostal muscle BF and vascular conductances (VC) than young rats during submaximal exercise.
METHODS
Mean arterial pressure and respiratory muscle BFs (via carotid artery catheter and radiolabeled microspheres, respectively) were measured at rest and during submaximal exercise in young (n = 9) and old (n = 7) Fischer 344 X Brown Norway rats.
RESULTS
At rest, diaphragm, intercostal, and transversus abdominis BFs and VCs were not different between groups (all, p > 0.10). During submaximal exercise, old compared to young rats had greater intercostal BF (40 ± 6 vs 25 ± 2 mL/min/100 g) and VC (0.30 ± 0.05 vs 0.18 ± 0.02 mL/min/mmHg/100 g) (both, p ≤ 0.01). Diaphragm and transversus abdominis BFs and VCs were not different between groups during exercise (all, p > 0.24).
CONCLUSIONS
These data demonstrate that intercostal muscle BF and VC are increased in old compared to young rats during submaximal exercise.
背景
在年轻成年大鼠的运动过程中，呼吸肌血流（BF）会大幅增加。随着年龄的增长，肺部功能会发生改变，因此我们假设，在亚最大运动期间，老年大鼠的肋间肌 BF 和血管传导率（VC）会比年轻大鼠更高。
方法
在休息和亚最大运动期间，通过颈动脉导管和放射性标记的微球分别测量年轻（n=9）和老年（n=7）Fischer 344 X 布朗-挪威大鼠的平均动脉压和呼吸肌 BF。
结果
在休息时，两组之间的膈肌、肋间肌和横腹肌 BF 和 VC 没有差异（均为 p>0.10）。在亚最大运动期间，与年轻大鼠相比，老年大鼠的肋间肌 BF（40±6 比 25±2 mL/min/100 g）和 VC（0.30±0.05 比 0.18±0.02 mL/min/mmHg/100 g）更高（均为 p≤0.01）。在运动期间，两组之间的膈肌和横腹肌 BF 和 VC 没有差异（均为 p>0.24）。
结论
这些数据表明，在亚最大运动期间，与年轻大鼠相比，老年大鼠的肋间肌 BF 和 VC 增加。
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