老年大鼠慢性心力衰竭对次最大运动期间呼吸肌和后肢血流的影响。
Effect of chronic heart failure in older rats on respiratory muscle and hindlimb blood flow during submaximal exercise.
作者信息
Smith Joshua R, Hageman K Sue, Harms Craig A, Poole David C, Musch Timothy I
机构信息
Department of Kinesiology, Kansas State University, Manhattan, KS, 66506, USA.
Department of Anatomy and Physiology, Kansas State University, Manhattan, KS, 66506, USA.
出版信息
Respir Physiol Neurobiol. 2017 Sep;243:20-26. doi: 10.1016/j.resp.2017.05.002. Epub 2017 May 7.
Submaximal exercise diaphragm blood flow (BF) is elevated in young chronic heart failure (CHF) rats, while it is unknown if this occurs in older animals. Respiratory and hindlimb muscle BFs (radiolabeled microspheres) were measured at rest and during submaximal exercise (20m/min, 5% grade) in older healthy (n=7) and CHF (n=6) Fischer 344X Brown Norway rats (27-29 mo old). Older CHF, compared to healthy, rats had greater (p<0.01) left ventricular end-diastolic pressure and right ventricle and lung weight (normalized to body weight). During submaximal exercise, respiratory and hindlimb muscle BFs increased (p<0.02) in both groups, while diaphragm BF was higher (CHF: 257±32; healthy: 121±9mL/min/100g, p<0.01) and hindlimb BF lower (CHF: 111±10; healthy: 133±12mL/min/100g, p=0.04) in older CHF compared to healthy rats. Submaximal exercise hindlimb BF was negatively related (r=-0.93; p=0.03) to diaphragm BF in older CHF rats. During submaximal exercise, diaphragm BF is elevated in older CHF compared to healthy rats in proportion to the compromised hindlimb BF.
在年轻的慢性心力衰竭（CHF）大鼠中，次极量运动时膈肌血流量（BF）会升高，而在老年动物中是否会出现这种情况尚不清楚。在静息状态和次极量运动（20米/分钟，坡度5%）期间，对老年健康（n=7）和CHF（n=6）的Fischer 344×Brown Norway大鼠（27 - 29月龄）测量了呼吸肌和后肢肌肉的BF（放射性微球法）。与健康大鼠相比，老年CHF大鼠的左心室舒张末期压力以及右心室和肺重量（相对于体重）更大（p<0.01）。在次极量运动期间，两组的呼吸肌和后肢肌肉BF均增加（p<0.02），但与健康大鼠相比，老年CHF大鼠的膈肌BF更高（CHF：257±32；健康：121±9毫升/分钟/100克，p<0.01），而后肢BF更低（CHF：111±10；健康：133±12毫升/分钟/100克，p=0.04）。在老年CHF大鼠中，次极量运动时后肢BF与膈肌BF呈负相关（r=-0.93；p=0.03）。在次极量运动期间，与健康大鼠相比，老年CHF大鼠的膈肌BF升高，且与后肢BF受损程度成比例。
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