Leicester Cancer Research Centre, Leicester Royal Infirmary, University of Leicester, Leicester, UK; Mechanisms of Cancer and Ageing Laboratory, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Leicester Cancer Research Centre, Leicester Royal Infirmary, University of Leicester, Leicester, UK.
Clin Oncol (R Coll Radiol). 2019 May;31(5):283-289. doi: 10.1016/j.clon.2019.02.003. Epub 2019 Feb 27.
Radiotherapy is still a treatment of choice for many malignancies, often in combination with other strategies. However, its efficacy is limited by the dose that can be safely administered without eliciting serious side-effects, as well as the fact that recurrence is common, particularly in large tumours. Combining radiotherapy with drugs that could sensitise cells to radiation and/or reduce the factors that promote the recovery of the surviving cancer cells is a promising approach. Ionising radiation has been shown to induce senescence and the accumulation of senescent cells creates a microenvironment that facilitates neoplastic growth. This provides a rationale to test the addition of anti-senescent drugs, some of which are already available in the clinic, to radiotherapy protocols. Here, we discuss the relevance of radiotherapy-induced senescent cell accumulation and the potential interventions to minimise its negative effects.
放射疗法仍然是许多恶性肿瘤的治疗选择，通常与其他策略结合使用。然而，其疗效受到限制，因为不能安全地给予足以产生严重副作用的剂量，而且复发很常见，尤其是在大型肿瘤中。将放射疗法与能够使细胞对辐射敏感和/或减少促进存活癌细胞恢复的因素的药物结合使用是一种很有前途的方法。已经表明，电离辐射会诱导衰老，并且衰老细胞的积累会产生促进肿瘤生长的微环境。这为测试添加抗衰老药物提供了依据，其中一些药物已经在临床上使用。在这里，我们讨论放射治疗诱导的衰老细胞积累的相关性，以及最小化其负面影响的潜在干预措施。
