Hedner J, Hedner T, Jonason J, Lundberg D
Neurosci Lett. 1981 Sep 25;25(3):317-20. doi: 10.1016/0304-3940(81)90411-0.
Anaesthetized male rats were injected intracerebroventricularly with the tripeptide, thyrotropin releasing hormone (TRH). Respiratory frequency (f), tidal volume (VT) and minute volume (VE) were measured in a closed whole body plethysmograph by a low pressure transducer connected to a Grass polygraph. TRH induced an approximately 50% increase in f, while VT was not altered. VE increased in the same proportion as f. Our results indicate that TRH neurons or TRH-sensitive receptors may be involved in the regulation of central respiratory activity.
对麻醉的雄性大鼠进行脑室内注射三肽促甲状腺激素释放激素（TRH）。通过连接到Grass多导记录仪的低压传感器，在封闭的全身体积描记器中测量呼吸频率（f）、潮气量（VT）和分钟通气量（VE）。TRH使f增加约50%，而VT未改变。VE与f以相同比例增加。我们的结果表明，TRH神经元或TRH敏感受体可能参与中枢呼吸活动的调节。
