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In response to: The validity of F-GE180 as a TSPO imaging agent.

作者信息

Albert Nathalie L, Unterrainer Marcus, Brendel Matthias, Kaiser Lena, Zweckstetter Markus, Cumming Paul, Bartenstein Peter

机构信息

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Department for NMR-Based Structural Biology, Max Planck Institute for Biophysical Chemistry, Goettingen, Germany.

出版信息

Eur J Nucl Med Mol Imaging. 2019 Jun;46(6):1208-1211. doi: 10.1007/s00259-019-04294-8. Epub 2019 Mar 2.

DOI:10.1007/s00259-019-04294-8
PMID:30826897
Abstract
摘要

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Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter.18kDa 转位蛋白(TSPO)放射性配体[F]GE-180 的特异性结合确认:XBD173 在多发性硬化症正常表现白质和灰质中的阻断研究。
Mol Imaging Biol. 2019 Oct;21(5):935-944. doi: 10.1007/s11307-019-01323-8.
2
The validity of F-GE180 as a TSPO imaging agent.F-GE180作为一种TSPO显像剂的有效性。
Eur J Nucl Med Mol Imaging. 2019 Jun;46(6):1205-1207. doi: 10.1007/s00259-019-4268-4. Epub 2019 Jan 17.
3
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
用于脑和外周炎症生物标志物 TSPO 和 COX-2 成像的示踪剂。
Int J Mol Sci. 2023 Dec 13;24(24):17419. doi: 10.3390/ijms242417419.
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Machine learning-based approach reveals essential features for simplified TSPO PET quantification in ischemic stroke patients.基于机器学习的方法揭示了简化 TSPO PET 定量在缺血性脑卒中患者中的关键特征。
Z Med Phys. 2024 May;34(2):218-230. doi: 10.1016/j.zemedi.2022.11.008. Epub 2023 Jan 20.
5
Longitudinal [F]GE-180 PET Imaging Facilitates In Vivo Monitoring of TSPO Expression in the GL261 Glioblastoma Mouse Model.纵向[F]GE - 180正电子发射断层显像有助于在GL261胶质母细胞瘤小鼠模型中对TSPO表达进行体内监测。
Biomedicines. 2022 Mar 22;10(4):738. doi: 10.3390/biomedicines10040738.
6
Differential Spatial Distribution of TSPO or Amino Acid PET Signal and MRI Contrast Enhancement in Gliomas.胶质瘤中TSPO或氨基酸PET信号与MRI对比增强的差异空间分布
Cancers (Basel). 2021 Dec 23;14(1):53. doi: 10.3390/cancers14010053.
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Impact of TSPO Receptor Polymorphism on [F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders.TSPO受体多态性对健康大脑以及神经肿瘤和神经退行性疾病的伪参考区域中[F]GE-180结合的影响。
Life (Basel). 2021 May 26;11(6):484. doi: 10.3390/life11060484.
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