University of Novi Sad Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection, Trg Dositeja Obradovića 3, 21000 Novi Sad, Serbia.
University of Novi Sad Faculty of Medicine, Oncology Institute of Vojvodina, Put doktora Goldmana 4, 21204 Sremska Kamenica, Serbia.
Food Chem. 2019 Jul 15;286:686-695. doi: 10.1016/j.foodchem.2019.02.049. Epub 2019 Feb 19.
Chemical composition and bioactivity of eight edible Vitis vinifera L. leaf varieties originating from Fruška Gora, Serbia, including two autochthonous varieties, were evaluated. The LC-MS/MS analysis confirmed the presence of 28 natural products in leaf samples, among which most abundant were glycosylated flavonoids, ellagic and chlorogenic acids. The highest amounts of most of the tested compounds were detected in leaves of autochthonous variety Sila. Bioactivity was assessed by a set of in vitro antioxidant, neuroprotective and cytotoxic assays. Leaves of all examined varieties exhibited average bioactivity, with leaves of autochthonous variety Župljanka standing out as the most promising sample. To conclude, investigated grapevine leaves proved to be a rich source of nutraceuticals, primarily antioxidants, and their further employment as medicinal food in human diet and beneficial raw material for food, pharmaceutical and cosmetic industries should be supported.
对源自塞尔维亚弗鲁斯卡戈拉的八种可食用葡萄叶品种（包括两个本土品种）的化学成分和生物活性进行了评估。LC-MS/MS 分析证实了叶样品中存在 28 种天然产物，其中含量最丰富的是糖苷化类黄酮、鞣花酸和绿原酸。在所测试的化合物中，大多数化合物在本土品种 Sila 的叶子中含量最高。通过一系列体外抗氧化、神经保护和细胞毒性测定来评估生物活性。所有被检测的品种的叶子都表现出平均的生物活性，其中本土品种Župljanka 的叶子表现最为突出。总之，研究发现葡萄叶是营养保健品的丰富来源，主要是抗氧化剂，它们可以作为药用食品添加到人类饮食中，也可以作为食品、制药和化妆品行业的有益原料。
