Miao R M, Tanga M J, Suk W A, Miller A, Reist E J
Int J Cancer. 1986 Apr 15;37(4):613-7. doi: 10.1002/ijc.2910370422.
The potential carcinogenicity of 3 azabenz(a)anthracenes was determined in vitro. The 3 compounds tested were 1-, 2-, and 9-azabenz(a)anthracene. The initial assay was chemical carcinogen-induced enhancement of anchorage-independent survival of Rauscher leukemia virus-infected Fischer rat embryo cells, 2FR(4)50 (2FR4). Cells treated with 2- and 9-azabenz(a)anthracene showed dose-dependent increased survival. After continued subculturing, the surviving cells from 2- and 9-azabenz(a)anthracene-treated cultures displayed morphological transformation and ability to grow in semi-solid medium. Mock-treated controls and I-azabenz(a)anthracene-treated cultures did not show either of these properties. These data suggest that certain azabenz(a)anthracenes are potential carcinogens.
在体外测定了3种氮杂苯并(a)蒽的潜在致癌性。所测试的3种化合物分别是1-、2-和9-氮杂苯并(a)蒽。初始试验是化学致癌物诱导的对感染劳斯氏白血病病毒的费希尔大鼠胚胎细胞2FR(4)50（2FR4）非锚定依赖性存活的增强。用2-和9-氮杂苯并(a)蒽处理的细胞显示出剂量依赖性的存活增加。在持续传代培养后，来自用2-和9-氮杂苯并(a)蒽处理的培养物中的存活细胞表现出形态转化以及在半固体培养基中生长的能力。模拟处理的对照和用1-氮杂苯并(a)蒽处理的培养物均未表现出这些特性。这些数据表明某些氮杂苯并(a)蒽是潜在的致癌物。
