多环烃在无细胞毒性情况下对仓鼠细胞的体外转化
Transformation of hamster cells in vitro by polycyclic hydrocarbons without cytotoxicity.
作者信息
Dipaolo J A, Donovan P J, Nelson R L
出版信息
Proc Natl Acad Sci U S A. 1971 Dec;68(12):2958-61. doi: 10.1073/pnas.68.12.2958.
Abstract
Treatment with either a flavone or benz(alpha)anthracene before the addition of a potent carcinogen, benzo(alpha)pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz(alpha)anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo(alpha)pyrene and 3-methylcholanthrene.
摘要
在添加强效致癌物苯并(α)芘或3-甲基胆蒽之前，用黄酮或苯并(α)蒽进行处理，可增强接种以形成集落的叙利亚仓鼠细胞的转化。7,8-苯并黄酮和苯并(α)蒽可预防致癌物的细胞毒性，而5,6-苯并黄酮则不能。结果清楚地表明，有可能将苯并(α)芘和3-甲基胆蒽的转化特性与毒性代谢特性区分开来。
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