Watanabe Ippei, Hoshi Hirotaka, Sato Miwako, Suzuki Kiyoshi
Medical Science Liaison Unit, Seikagaku Corporation.
Central Research Laboratories, Seikagaku Corporation.
Chem Pharm Bull (Tokyo). 2019;67(3):277-283. doi: 10.1248/cpb.c18-00890.
The purpose of this study is to evaluate the usefulness of the rheological properties and adhesive force of ophthalmic viscosurgical devices (OVDs) as parameters for understanding and identifying the surgical behavior of cohesive and dispersive OVDs. The apparent viscosity, and the storage and loss moduli (dynamic rheological parameters) of 50% chondroitin sulfate (CS), 3% sodium hyaluronate (HA), Shellgan (the combination of 3% HA and 4% CS), Opegan (1% HA with a low molecular mass) and Opegan-Hi (1% HA with a high molecular mass) were obtained with a rheometer. The adhesive force of each sample was measured by using a texture analyzer. Opegan-Hi showed a solid-like behavior, while 50% CS showed a fluid-like behavior from their apparent viscosity and dynamic rheological parameters. Shellgan, 3% HA, and Opegan exhibited similar rheological properties and intermediate characteristics between Opegan-Hi and 50% CS, although their respective values were slightly different. Among these OVD samples, the adhesive force was higher in the order of 50% CS > Shellgan, 3% HA > Opegan > Opegan-Hi. The adhesive force of dispersive OVDs tended to be higher than that of cohesive OVDs, which correlated well with the removal times of OVDs from the eye that have previously been reported. In conclusion, we demonstrated that cohesive OVDs and dispersive OVDs have particular rheological and adhesive properties that can be applied to identify both types. These parameters obtained in this study provide useful information for a greater understanding and prediction of the behavior of OVDs in the eye during surgery.
本研究的目的是评估眼科粘弹剂（OVDs）的流变学特性和粘附力，将其作为理解和识别粘性及分散性OVDs手术行为的参数。使用流变仪获得了50%硫酸软骨素（CS）、3%透明质酸钠（HA）、Shellgan（3% HA与4% CS的组合）、Opegan（1%低分子量HA）和Opegan-Hi（1%高分子量HA）的表观粘度、储能模量和损耗模量（动态流变学参数）。使用质构分析仪测量每个样品的粘附力。从表观粘度和动态流变学参数来看，Opegan-Hi表现出类似固体的行为，而50% CS表现出类似流体的行为。Shellgan、3% HA和Opegan表现出相似的流变学特性，以及介于Opegan-Hi和50% CS之间的中间特性，尽管它们各自的值略有不同。在这些OVD样品中，粘附力从高到低依次为50% CS＞Shellgan、3% HA＞Opegan＞Opegan-Hi。分散性OVDs的粘附力往往高于粘性OVDs，这与先前报道的OVDs从眼中清除的时间密切相关。总之，我们证明了粘性OVDs和分散性OVDs具有特定的流变学和粘附特性，可用于识别这两种类型。本研究中获得的这些参数为更好地理解和预测手术过程中OVDs在眼中的行为提供了有用信息。
