混合聚合物系统：通过混合市售设备创建的新型眼科粘弹性手术装置。
Mixed polymeric systems: New ophthalmic viscosurgical device created by mixing commercially available devices.
机构信息
From the Eye Clinic (Tognetto, D'Aloisio, Cecchini) and the Department of Engineering and Architecture (Lapasin), University of Trieste, Trieste, Italy.
From the Eye Clinic (Tognetto, D'Aloisio, Cecchini) and the Department of Engineering and Architecture (Lapasin), University of Trieste, Trieste, Italy.
出版信息
J Cataract Refract Surg. 2017 Jan;43(1):109-114. doi: 10.1016/j.jcrs.2016.11.035.
PURPOSE
To evaluate the rheological properties of mixtures of different commercially available ophthalmic viscosurgical devices (OVDs) containing sodium hyaluronate and chondroitin sulfate.
SETTING
Eye Clinic, University of Trieste, Trieste, Italy.
DESIGN
Laboratory study.
METHODS
Blends were obtained combining a superviscous cohesive OVD (Healon GV [sodium hyaluronate 1%]) and a medium-viscosity dispersive OVD (Viscoat [sodium hyaluronate 3.0%-chondroitin sulfate 4.0%]). The 2 substances were combined in different ratios, and the rheological characteristics were analyzed to find the optimum proportion. A new viscous dispersive OVD, Discovisc (hyaluronic acid 1.6%-chondroitin sulfate 4.0%) was evaluated for comparison. The storage modulus, loss modulus, crossover point, complex viscosity, shear viscosity, and pseudoplasticity were studied.
RESULTS
The rheological properties of the mixed solution (1:1 and 3:1) showed intermediate characteristics in comparison with the 2 original substances, characterized by a viscosity comparable to that of the superviscous cohesive OVD, but at a higher shear rate (similar to the medium-viscosity dispersive OVD). The new viscous dispersive OVD performed similarly to the medium-viscosity dispersive OVD at low shear rates but was comparable to the superviscous cohesive OVD at high shear rates.
CONCLUSIONS
The mixture of dispersive and cohesive rheological properties in a single OVD might be an advantage during cataract surgery.
目的
评估含有透明质酸钠和硫酸软骨素的不同市售眼科黏弹剂（OVD）混合物的流变特性。
地点
意大利的的里雅斯特大学眼科诊所。
设计
实验室研究。
方法
通过混合一种超黏弹性的 OVD（Healon GV [1%透明质酸钠]）和一种中黏度分散性 OVD（Viscoat [3.0%透明质酸钠-4.0%硫酸软骨素]）来获得混合物。将这两种物质以不同的比例混合，并分析流变特性以找到最佳比例。还评估了一种新的黏性分散性 OVD（Discovisc [1.6%透明质酸钠-4.0%硫酸软骨素]）用于比较。研究了储能模量、损耗模量、交叉点、复数黏度、剪切黏度和假塑性。
结果
混合溶液（1:1 和 3:1）的流变特性与两种原始物质相比具有中间特性，其黏度与超黏弹性的 OVD 相当，但在较高的剪切速率下（类似于中黏度分散性 OVD）。新型黏性分散性 OVD 在低剪切速率下的性能与中黏度分散性 OVD 相似，但在高剪切速率下与超黏弹性的 OVD 相当。
结论
在白内障手术中，单一 OVD 中分散性和黏性流变特性的混合物可能是一个优势。
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