a Pharmaceutics Research Center, Institute of Neuropharmacology , Kerman University of Medical Sciences , Kerman , Iran.
b Department of Molecular Medicine , Institute of Medical Biotechnology, National Institute for Genetic Engineering and Biotechnology , Tehran , Iran.
Autophagy. 2019 Jan;15(1):4-33. doi: 10.1080/15548627.2018.1509171. Epub 2018 Sep 13.
Nanomaterials have gained a rapid increase in use in a variety of applications that pertain to many aspects of human life. The majority of these innovations are centered on medical applications and a range of industrial and environmental uses ranging from electronics to environmental remediation. Despite the advantages of NPs, the knowledge of their toxicological behavior and their interactions with the cellular machinery that determines cell fate is extremely limited. This review is an attempt to summarize and increase our understanding of the mechanistic basis of nanomaterial interactions with the cellular machinery that governs cell fate and activity. We review the mechanisms of NP-induced necrosis, apoptosis and autophagy and potential implications of these pathways in nanomaterial-induced outcomes. Abbreviations: Ag, silver; CdTe, cadmium telluride; CNTs, carbon nanotubes; EC, endothelial cell; GFP, green fluorescent protein; GO, graphene oxide; GSH, glutathione; HUVECs, human umbilical vein endothelial cells; NP, nanoparticle; PEI, polyethylenimine; PVP, polyvinylpyrrolidone; QD, quantum dot; ROS, reactive oxygen species; SiO, silicon dioxide; SPIONs, superparamagnetic iron oxide nanoparticles; SWCNT, single-walled carbon nanotubes; TiO, titanium dioxide; USPION, ultra-small super paramagnetic iron oxide; ZnO, zinc oxide.
纳米材料在各种应用中得到了快速的增加，这些应用涉及到人类生活的许多方面。这些创新大多集中在医学应用和一系列工业和环境应用上，从电子产品到环境修复。尽管纳米粒子有很多优点，但它们的毒理学行为及其与决定细胞命运的细胞机制的相互作用的知识极其有限。这篇综述试图总结并增加我们对纳米材料与控制细胞命运和活性的细胞机制相互作用的机制基础的理解。我们综述了纳米颗粒诱导的坏死、凋亡和自噬的机制，以及这些途径在纳米颗粒诱导的结果中的潜在意义。缩写：Ag，银；CdTe，碲化镉；CNTs，碳纳米管；EC，内皮细胞；GFP，绿色荧光蛋白；GO，氧化石墨烯；GSH，谷胱甘肽；HUVECs，人脐静脉内皮细胞；NP，纳米颗粒；PEI，聚乙烯亚胺；PVP，聚乙烯吡咯烷酮；QD，量子点；ROS，活性氧；SiO，二氧化硅；SPIONs，超顺磁性氧化铁纳米颗粒；SWCNT，单壁碳纳米管；TiO，二氧化钛；USPION，超小超顺磁性氧化铁；ZnO，氧化锌。
