Venegas J G, Hales C A, Strieder D J
J Appl Physiol (1985). 1986 Mar;60(3):1025-30. doi: 10.1152/jappl.1986.60.3.1025.
To identify a general relationship between eucapnic oscillatory flow (Vosc) and frequency (f) in high-frequency ventilation (HFV), we searched the literature for eucapnic HFV data in different mammalian species. We found suitable results for rat, rabbit, monkey, dog, human, and horse, which we expressed in terms of two dimensionless variables, Q = Vosc/Va and F = f/(VA/VD), with VA the alveolar ventilation and VD the volume of the conducting airways. The experimental HFV data define the linear regression equation in Q = 0.54 In F + 0.92 (R = 0.94). Krogh's equation for conventional ventilation (CV), Vosc = VA + fVD, in dimensionless terms becomes Q = 1 + F, which is valid for low F. The intersection of the CV and HFV equations at F = 5.0 defines a transition frequency, ft = 5.0 (VA/VD). At that point the alveolar ventilation per breath, VA/f, represents 20% of VD, and tidal volume (VT) equals 1.20 VD. For eucapnia ft ranges from 5.9 Hz in the rat to 0.9 Hz in the dog. The dimensional form of our HFV equation, VA = 0.13 (VT/VD)1.2 (VTf) is very similar to other empirical equations reported for dogs in noneucapnic settings. Therefore the dimensionless equation should also be valid within a species at noneucapnic settings.
为了确定高频通气（HFV）中呼气末二氧化碳分压稳定时的振荡气流（Vosc）与频率（f）之间的一般关系，我们在文献中搜索了不同哺乳动物物种的呼气末二氧化碳分压稳定时的高频通气数据。我们找到了大鼠、兔子、猴子、狗、人类和马的合适结果，并用两个无量纲变量来表示，即Q = Vosc/Va和F = f/(VA/VD)，其中VA为肺泡通气量，VD为传导气道容积。实验性高频通气数据定义了线性回归方程Q = 0.54 ln F + 0.92（R = 0.94）。传统通气（CV）的克罗格方程Vosc = VA + fVD，无量纲形式变为Q = 1 + F，该式在低F时有效。CV方程与HFV方程在F = 5.0处的交点定义了一个转换频率ft = 5.0 (VA/VD)。此时，每次呼吸的肺泡通气量VA/f占VD的20%，潮气量（VT）等于1.20 VD。对于呼气末二氧化碳分压稳定的情况，ft范围从大鼠的5.9 Hz到狗的0.9 Hz。我们的高频通气方程的量纲形式VA = 0.13 (VT/VD)1.2 (VTf)与非呼气末二氧化碳分压稳定情况下报道的狗的其他经验方程非常相似。因此，无量纲方程在非呼气末二氧化碳分压稳定的情况下在一个物种内也应该是有效的。
