新型给药技术采用纹身机给药，其输送的药物剂量是多少？
How much medication is delivered in a novel drug delivery technique that uses a tattoo machine?
机构信息
Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP)/SP, Brazil.
Department of Aerospace Science and Technology - DCTA Aeronautics and Space Institute - IAE, Department of Chemistry, São José dos Campos/SP, Brazil.
出版信息
Int J Dermatol. 2019 Jun;58(6):750-755. doi: 10.1111/ijd.14408. Epub 2019 Mar 3.
BACKGROUND
Even though dermatologists often perform drug delivery procedures, it is necessary to assess their safety.
OBJECTIVE
Quantify the amount of medication delivered using the MMP drug delivery technique and outline other safety parameters.
METHODS
Using a simple and novel technique, we attempted to quantify the amount of medication delivered by weighing human skin samples before and after delivery.
RESULTS
In drug delivery done on human skin using a liquid with a density of 1,271,460 μg/ml (the values expressed in this manuscript are in µg), a needling density of 570 perforations/cm , and a needling depth of 300 microns, we estimate that 1,175 μg/cm were delivered (standard deviation 601 μg/cm , standard error 190 μg/cm ).
LIMITATIONS
This result is only applicable to the protocol proposed in this study for the MMP drug delivery technique.
CONCLUSION
The MMP drug delivery technique injects small amounts of medication (1,175 μg/cm ) homogeneously into the dermis.
背景
尽管皮肤科医生经常进行药物输送程序，但仍有必要评估其安全性。
目的
使用 MMP 药物输送技术定量输送的药物量，并概述其他安全参数。
方法
我们使用一种简单新颖的技术，尝试通过称重输送前后的人体皮肤样本来定量输送的药物量。
结果
在使用密度为 1,271,460μg/ml 的液体（本文献中表达的值为µg）对人体皮肤进行药物输送，针刺密度为 570 个穿孔/cm，针刺深度为 300 微米的情况下，我们估计输送了 1,175μg/cm（标准偏差为 601μg/cm，标准误差为 190μg/cm）。
局限性
该结果仅适用于本研究中 MMP 药物输送技术的方案。
结论
MMP 药物输送技术将少量药物（1,175μg/cm）均匀地注入真皮。
Zotero 插件