Pregnancy Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Gynaecol Obstet. 2019 May;145(2):149-157. doi: 10.1002/ijgo.12799.
Studies on the impact of adenomyosis and its pregnancy complications have yielded conflicting results.
To determine the likelihood of adverse pregnancy outcomes among women with adenomyosis relative to women without adenomyosis.
PubMed, Embase, Scopus, and Web of Science were searched for studies published up to June 15, 2018.
Observational studies with medically confirmed pregnancy outcomes as endpoints.
Two researchers independently screened and selected relevant studies. Dichotomous data for all adverse pregnancy outcomes were expressed as an odds ratio (OR) with 95% confidence interval (CI), and combined in a meta-analysis by using a random-effects model.
Six studies (322 cases and 9420 controls) were eligible for inclusion in the meta-analysis. Women with adenomyosis had an increased likelihood of preterm birth (OR, 3.05; 95% CI, 2.08-4.47; P˂0.001), small for gestational age (OR, 3.22; 95% CI, 1.71-6.08; P˂0.001), and pre-eclampsia (OR, 4.35; 95% CI, 1.07-17.72; P=0.042).
Adenomyosis seems to have a detrimental impact on pregnancy outcomes, resulting in a higher likelihood of preterm birth, small for gestational age, and pre-eclampsia.
关于子宫腺肌病及其妊娠并发症影响的研究结果相互矛盾。
旨在确定与无子宫腺肌病的女性相比，患有子宫腺肌病的女性发生不良妊娠结局的可能性。
检索了截至 2018 年 6 月 15 日在 PubMed、Embase、Scopus 和 Web of Science 上发表的研究。
以医学上确认的妊娠结局为终点的观察性研究。
两名研究人员独立筛选和选择了相关研究。所有不良妊娠结局的二项数据表示为比值比（OR）及其 95%置信区间（CI），并使用随机效应模型进行荟萃分析合并。
有 6 项研究（322 例病例和 9420 例对照）符合荟萃分析的纳入标准。患有子宫腺肌病的女性发生早产（OR，3.05；95%CI，2.08-4.47；P＜0.001）、小于胎龄儿（OR，3.22；95%CI，1.71-6.08；P＜0.001）和子痫前期（OR，4.35；95%CI，1.07-17.72；P=0.042）的可能性增加。
子宫腺肌病似乎对妊娠结局有不利影响，导致早产、小于胎龄儿和子痫前期的可能性增加。
