子宫腺肌病与不孕。
Adenomyosis and infertility.
机构信息
Department of Obstetrics and Gynecology, The George Washington University Hospital, Washington, DC, USA.
Department of Pathology, Wayne State University, Detroit, MI, USA.
出版信息
J Assist Reprod Genet. 2022 May;39(5):1027-1031. doi: 10.1007/s10815-022-02476-2. Epub 2022 Mar 28.
PURPOSE
Adenomyosis is a poorly understood entity with no unified treatment protocol. It has been thought to only affect the quality of life of older women, but growing evidence is highlighting the increased frequency of adenomyosis in younger patients and its possible effects on fertility outcomes. This can have a great impact on how clinicians screen, diagnose, and treat this condition. The aim of this review is to explore the relationship between adenomyosis and infertility.
METHODS
A literature search of the keywords "adenomyosis", "infertility", "pregnancy" and "fertility" was conducted using the PubMed and Medline search engines. The articles selected were observational, systematic reviews, meta-analyses, and randomized controlled trials. The search was limited to English, abstracts were screened, and articles were selected.
RESULTS
The literature reports lower clinical pregnancy rates, lower live birth rates, higher miscarriage rates, and higher odds of adverse obstetric outcomes in patients with adenomyosis. Treatment seems to be associated with higher pregnancy rates and live births rates.
CONCLUSION
An association between adenomyosis and infertility seems to exist, and treatment could lead to improved fertility outcomes.
目的
子宫腺肌病是一种发病机制尚未明确的疾病，目前尚无统一的治疗方案。人们认为它只会影响老年女性的生活质量，但越来越多的证据表明，年轻患者中子宫腺肌病的发病率越来越高，其可能对生育结局产生影响。这可能会极大地影响临床医生对该疾病的筛查、诊断和治疗方式。本综述旨在探讨子宫腺肌病与不孕之间的关系。
方法
使用 PubMed 和 Medline 搜索引擎，以“adenomyosis”、“infertility”、“pregnancy”和“fertility”为关键词进行文献检索。选择的文章为观察性研究、系统评价、荟萃分析和随机对照试验。检索限定为英文，筛选摘要，并选择文章。
结果
文献报道，子宫腺肌病患者的临床妊娠率、活产率较低，流产率较高，不良产科结局的几率也较高。治疗似乎与较高的妊娠率和活产率相关。
结论
子宫腺肌病与不孕之间似乎存在关联，治疗可能会改善生育结局。
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