Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Magn Reson Med. 2019 Jul;82(1):189-201. doi: 10.1002/mrm.27708. Epub 2019 Mar 3.
To introduce an accurate, rapid, and practical method for active B field mapping based on the double-angle method (DAM) in the steady-state (SS) signal regime.
We introduced and evaluated the performance of the SS-DAM approach to map the B field and compared the results to those calculated from the conventional DAM approach. Similar to DAM, SS-DAM uses the signal intensity ratio of 2 magnitude images acquired with different flip angles using the spoiled gradient recalled echo sequence. However, unlike DAM, in SS-DAM, these 2 spoiled gradient recalled echo images are acquired with very short TR, which allows substantially reduced acquisition time. Numerical, phantom, and in vivo brain imaging analyses, representing a wide range of T s and large B variation, were conducted. Methods for further accelerating acquisition were also investigated.
Our results demonstrate the potential of the SS-DAM approach to be applied widely in the clinical setting. B maps derived from SS-DAM were demonstrated to be quantitatively comparable to those derived from DAM but were derived much more rapidly. Large-volume B maps were obtained at a field strength of 3 tesla within clinically acceptable acquisition times.
SS-DAM permits accurate B mapping in the clinical setting, with whole-brain coverage in less than 1 min.
介绍一种基于稳态(SS)信号域中双角度法(DAM)的准确、快速且实用的主动 B 场映射方法。
我们引入并评估了 SS-DAM 方法在 B 场映射中的性能,并将结果与传统 DAM 方法的计算结果进行了比较。与 DAM 类似,SS-DAM 使用具有不同翻转角的 2 个幅度图像的信号强度比,使用扰相梯度回波序列进行采集。但是,与 DAM 不同,在 SS-DAM 中,这 2 个扰相梯度回波图像使用非常短的 TR 进行采集,这允许大大减少采集时间。进行了数值、体模和活体脑成像分析,代表了广泛的 T s 和大的 B 变化范围。还研究了进一步加速采集的方法。
我们的结果证明了 SS-DAM 方法在临床环境中具有广泛应用的潜力。从 SS-DAM 得出的 B 图被证明在定量上可与从 DAM 得出的 B 图相媲美,但得出速度要快得多。在 3 特斯拉的场强下,可在可接受的采集时间内获得大体积的 B 图。
SS-DAM 允许在临床环境中进行准确的 B 场映射,全脑覆盖时间不到 1 分钟。