Suppr超能文献

中国新疆蒙古族群体常染色体多位点短串联重复序列的遗传分布及法医学评估。

Genetic distribution and forensic evaluation of multiplex autosomal short tandem repeats in the Chinese Xinjiang Mongolian group.

机构信息

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.

Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China.

出版信息

J Zhejiang Univ Sci B. 2019;20(3):287-290. doi: 10.1631/jzus.B1800279.

Abstract

To further enrich the genetic data of the Chinese Xinjiang Mongolian group, the genetic distribution and forensic parameters of 19 autosomal short tandem repeats (STRs) were investigated. Altogether, 249 alleles were observed in these 19 STRs. The mean values of the polymorphism information content (PIC), match probability (MP), discrimination power (DP), and probability of exclusion (PE) for these 19 STRs were 0.7775, 0.0699, 0.9301, and 0.6085, respectively. Additionally, the cumulative DP and PE values obtained in the Mongolian group were 0.999 999 999 999 999 999 999 995 67 and 0.999 999 992 163, respectively. Furthermore, population genetic analysis of the Mongolian group and 20 published populations was conducted based on the population data of 15 overlapping STRs. Genetic distances indicated that the Mongolian group had closer genetic similarities with the Uyghur, Xibe, and other Chinese populations rather than the other continental populations. Multidimensional scaling analysis further revealed that the Mongolian group possessed similar genetic distributions as most Chinese populations. To sum it all up, these STRs could be used as an extremely efficient tool for forensic applications in the Xinjiang Mongolian group.

摘要

为了进一步丰富中国新疆蒙古族群体的遗传数据,本研究调查了 19 个常染色体短串联重复序列(STRs)的遗传分布和法医学参数。在这 19 个 STRs 中观察到 249 个等位基因。这些 19 个 STRs 的多态信息含量(PIC)、匹配概率(MP)、鉴别能力(DP)和排除概率(PE)的平均值分别为 0.7775、0.0699、0.9301 和 0.6085。此外,蒙古族群体获得的累积 DP 和 PE 值分别为 0.9999999999999999999999567 和 0.999999992163。此外,基于 15 个重叠 STRs 的人群数据,对蒙古族群体与 20 个已发表人群进行了群体遗传分析。遗传距离表明,蒙古族群体与维吾尔族、锡伯族等中国人群具有更密切的遗传相似性,而与其他大陆人群则没有。多维尺度分析进一步表明,蒙古族群体与大多数中国人群具有相似的遗传分布。综上所述,这些 STR 可作为新疆蒙古族群体法医学应用的一种非常有效的工具。

相似文献

本文引用的文献

5
12 Y-STRs haplotypes in Chinese Naxi ethnic minority group.中国纳西族群体中的12个Y染色体短串联重复序列单倍型
Forensic Sci Int. 2008 Jan 30;174(2-3):244-8. doi: 10.1016/j.forsciint.2007.03.021. Epub 2007 May 25.
6
Informativeness of genetic markers for inference of ancestry.用于推断血统的遗传标记的信息性。
Am J Hum Genet. 2003 Dec;73(6):1402-22. doi: 10.1086/380416. Epub 2003 Nov 20.

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验