Williams Tamsin, Brechin Donald, Muncer Steven, Mukerji Nitin, Evans Stephen, Anderson Natasha
a Alder Hey Children's NHS Foundation Trust, Psychology, Developmental Paediatrics, ASD Pathway, Alder Hey Children's Hospital , Liverpool , United Kingdom of Great Britain and Northern Ireland.
b Clinical Psychology, James Cook University Hospital , Middlesbrough , United Kingdom of Great Britain and Northern Ireland.
Br J Neurosurg. 2019 Aug;33(4):383-387. doi: 10.1080/02688697.2019.1571163. Epub 2019 Mar 4.
Much of the research exploring psychological distress with meningioma stem from studies including several brain tumour types (including malignant tumours) meaning that focus on meningioma is limited and that conclusions are based on small samples. Moreover, contradictory findings have been reported regarding the effects of meningioma on mood. Here, the authors present a study exploring pre and post mood scores in meningioma only patients using a sample size larger than any previous research attempt. : The Hospital Anxiety and Depression Scale (HADS) was used as an objective measure of mood in a clinical sample of 184 UK patients pre and post meningioma removal surgery. Repeated measures designs were used to assess for significant differences in depression and anxiety scores before and after surgery, chi-squared analyses were used to establish for clinically significant change. : The study revealed a significant decrease, and a medium effect size, in mean depression scores after surgery to remove the meningioma (=.002, =0.35). However, no significant effect was found following meningioma removal and anxiety scores (=.113, =0.17). No significant effects were determined between mood and meningioma location. A discussion of the findings, and potential implications, is presented.
许多探索脑膜瘤患者心理困扰的研究源于包含多种脑肿瘤类型（包括恶性肿瘤）的研究，这意味着对脑膜瘤的关注有限，且结论基于小样本。此外，关于脑膜瘤对情绪的影响，已有相互矛盾的研究结果报道。在此，作者开展了一项研究，在仅患有脑膜瘤的患者中探索术前和术后的情绪评分，样本量比以往任何研究尝试都大。在184名英国患者的临床样本中，使用医院焦虑抑郁量表（HADS）作为情绪的客观测量指标，这些患者在接受脑膜瘤切除手术前后均接受了评估。采用重复测量设计来评估手术前后抑郁和焦虑评分的显著差异，使用卡方分析来确定临床上的显著变化。该研究显示，切除脑膜瘤后，平均抑郁评分显著下降，效应量中等（P =.002，Cohen's d = 0.35）。然而，切除脑膜瘤后焦虑评分未发现显著影响（P =.113，Cohen's d = 0.17）。情绪与脑膜瘤位置之间未发现显著影响。文中对研究结果及潜在影响进行了讨论。
