接受美沙酮治疗的儿科肿瘤患者的QT间期延长
QT Interval Prolongation in the Pediatric Oncologic Population on Methadone.
作者信息
Piccininni Jenna A, Killinger James S, Hammad Hoda T, Gerber Linda M, Dayton Jeffrey D
机构信息
Division of Pediatric Cardiology, NewYork Presbyterian/Columbia University Medical Center, Morgan Stanley Children's Hospital of New York.
Departments of Pediatrics.
出版信息
J Pediatr Hematol Oncol. 2020 Mar;42(2):e121-e124. doi: 10.1097/MPH.0000000000001444.
Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.
已经对服用美沙酮的成年人进行了研究，以确定QTc监测的必要频率，但尚未达成共识，且尚未在儿科人群中进行类似研究。这项回顾性研究的目的是确定儿科肿瘤患者中与使用美沙酮相关的QTc间期延长的发生率。总体而言，18%的患者出现了QTc间期延长。这些患者的基线QTc间期较长，并且正在使用更多可延长QTc间期的药物。我们的数据表明，这些变量可能能够对需要更频繁监测的患者进行风险分层。
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