Department of Life Sciences, University of Siena, Via Aldo Moro 2, 53100, Siena, Italy.
Cell Mol Life Sci. 2019 Aug;76(16):3249-3261. doi: 10.1007/s00018-019-03058-9. Epub 2019 Mar 4.
In addition to their modulation through de novo expression and degradation, surface levels of chemokine receptors are tuned by their ligand-dependent recycling to the plasma membrane, which ensures that engaged receptors become rapidly available for further rounds of signaling. Dysregulation of this process contributes to the pathogenesis of chronic lymphocytic leukemia (CLL) by enhancing surface expression of chemokine receptors, thereby favoring leukemic cell accumulation in the protective niche of lymphoid organs. In this review, we summarize our current understanding of the process of chemokine receptor recycling, focusing on the impact of its dysregulation in CLL.
除了通过从头表达和降解进行调节外，趋化因子受体的表面水平还通过其配体依赖性的再循环到质膜进行调节，这确保了结合的受体可迅速用于进一步的信号转导。该过程的失调通过增强趋化因子受体的表面表达，从而有利于白血病细胞在淋巴器官的保护性龛位中积累，从而导致慢性淋巴细胞白血病（CLL）的发病机制。在这篇综述中，我们总结了我们对趋化因子受体再循环过程的现有认识，重点介绍了其在 CLL 中的失调的影响。
