Stone M M, Mulvihill S J, Lewin K J, Fonkalsrud E W
J Pediatr Surg. 1986 Mar;21(3):267-70. doi: 10.1016/s0022-3468(86)80851-x.
Total intraperitoneal (IP) nutrition was studied in a rabbit model. A mixture of 10% dextrose, 2% amino acids, and 3% lipids was continuously administered to 28 rabbits as their sole nutritional source for 21 days. Twenty rabbits received the solution via IP catheters; 8 of these underwent 50% small bowel resection (SBR) prior to IP infusion. As controls, 8 rabbits were administered the same solution intravenously (IV-TPN). Survival was 75% in both experimental and control groups. Weight gain was similar in IV- and IP-infused rabbits after 21 days. No significant decrease in body weight or changes in blood chemistry occurred after 50% SBR. A mild chemical peritonitis was seen with IP nutrition which resolved after discontinuing the infusions. Biochemical and histologic liver toxicity was more severe in the IV controls than the IP-infused rabbits. We conclude total calorie support can be delivered thorough the peritoneal cavity on a long-term basis; 50% SBR minimally affects IP absorption of nutrients; and the liver dysfunction seen after IV-nutrition is less severe with IP nutrition.
在兔模型中研究了全腹腔内（IP）营养。将10%葡萄糖、2%氨基酸和3%脂质的混合物连续给予28只兔子，作为它们唯一的营养来源，持续21天。20只兔子通过IP导管接受该溶液；其中8只在IP输注前进行了50%小肠切除术（SBR）。作为对照，8只兔子静脉内给予相同溶液（IV-TPN）。实验组和对照组的存活率均为75%。21天后，静脉内和IP输注的兔子体重增加相似。50% SBR后，体重没有显著下降，血液化学指标也没有变化。IP营养时可见轻度化学性腹膜炎，停止输注后可缓解。IV对照组的生化和组织学肝毒性比IP输注的兔子更严重。我们得出结论，总热量支持可以长期通过腹腔提供；50% SBR对IP营养物质吸收的影响最小；IP营养时IV营养后出现的肝功能障碍较轻。
