Lane S L, Lindstrom R L, Cameron J D, Thomas R H, Mindrup E A, Waring G O, McCarey B E, Binder P S
J Cataract Refract Surg. 1986 Jan;12(1):50-60. doi: 10.1016/s0886-3350(86)80057-8.
Polysulfone is a thermoplastic compound first synthesized in 1965. A unique characteristic of polysulfone is its high refractive index (1.633), which allows very thin optical lenses to be manufactured. Over the last five years, D. Peter Choyce has surgically implanted over 40 polysulfone lenses into eyes of his patients. Analysis of his data indicates that polysulfone intraocular lenses are capable of correcting large refractive errors. Based on his work, a multicenter study was undertaken to evaluate the safety and efficacy of polysulfone as an intracorneal lens material in laboratory models. Four monkeys, eight baboons, and 24 cats were used as laboratory models; 5.0-mm to 6.0-mm diameter hyperopic (+28.5 diopter) and myopic (-17.0 and -25.5 diopter) lenses were surgically implanted within the corneal stroma in one eye of each of the laboratory models while a sham lamellar dissection was performed in the other eye. One hundred percent (4/4) of monkey eyes, 12.5% (1/8) of baboon eyes, and 70.0% (18/24) of cat eyes maintained clear media by ophthalmoscopic examination at follow-ups ranging from three to six months. Complications included both visually and nonvisually significant interface opacities, lens extrusion, anterior corneal necrosis, refractile particles, and epithelial thinning.
聚砜是一种于1965年首次合成的热塑性化合物。聚砜的一个独特特性是其高折射率（1.633），这使得可以制造非常薄的光学镜片。在过去五年中，D.彼得·乔伊斯已通过手术将40多个聚砜镜片植入他的患者眼中。对他的数据进行分析表明，聚砜人工晶状体能够矫正大的屈光不正。基于他的工作，开展了一项多中心研究，以评估聚砜作为角膜内透镜材料在实验室模型中的安全性和有效性。使用了4只猴子、8只狒狒和24只猫作为实验室模型；在每个实验室模型的一只眼睛的角膜基质内通过手术植入直径为5.0毫米至6.0毫米的远视（+28.5屈光度）和近视（-17.0和-25.5屈光度）镜片，而在另一只眼睛进行假板层剥离。在三至六个月的随访中，通过检眼镜检查，100%（4/4）的猴眼、12.5%（1/8）的狒狒眼和70.0%（18/24）的猫眼保持了透明介质。并发症包括视觉上和非视觉上显著的界面混浊、晶状体挤出、角膜前部坏死、折射颗粒和上皮变薄。
