Deg J K, Binder P S
Ophthalmology Research Laboratory, Sharp Cabrillo Hospital, San Diego, California.
Ophthalmology. 1988 Apr;95(4):506-15. doi: 10.1016/s0161-6420(88)33169-6.
The authors performed 13 myopic intracorneal polysulfone implants in a baboon model using two different implant designs. In the initial series, they used eight lenticules 5 to 6 mm in diameter with a central thickness greater than 0.15 mm. These failed 6 days to 6 months after surgery. The second series of five implants 4 to 5 mm in diameter with a thinner central thickness and improved edge design was better tolerated initially, but only two of five corneas remained clear 27 months after surgery. Clinical failure was associated with corneal neovascularization and opacification posterior to the implant or aseptic necrosis of the cornea overlying the implant. In most eyes, the anterior stroma was hypocellular anterior to the implant. Numerous vacuolated keratocytes and scattered eosinophils were detected posterior to the implant. In one case, lipid deposition was confirmed posterior to the lenticule. The authors conclude that solid polysulfone intrastromal implants are not biocompatible with the baboon cornea.
作者在狒狒模型中使用两种不同的植入物设计进行了13次近视性角膜聚砜植入。在最初的系列中，他们使用了8个直径为5至6毫米、中央厚度大于0.15毫米的晶状体。这些在术后6天至6个月失败。第二系列的5个植入物直径为4至5毫米，中央厚度更薄且边缘设计有所改进，最初耐受性更好，但术后27个月时5只角膜中只有2只保持透明。临床失败与植入物后方的角膜新生血管形成和混浊或植入物上方角膜的无菌性坏死有关。在大多数眼中，植入物前方的前基质细胞较少。在植入物后方检测到大量空泡化的角膜细胞和散在的嗜酸性粒细胞。在1例中，晶状体后方证实有脂质沉积。作者得出结论，固态聚砜基质内植入物与狒狒角膜不具有生物相容性。
