Institute of Health and Biomedical Innovation (IHBI), School of Biomedical Sciences, 60 Musk Avenue, Queensland University of Technology Kelvin Grove, Queensland 4059, Australia.
Institute of Health and Biomedical Innovation (IHBI), School of Biomedical Sciences, 60 Musk Avenue, Queensland University of Technology Kelvin Grove, Queensland 4059, Australia.
Gene. 2019 May 25;698:107-112. doi: 10.1016/j.gene.2019.02.067. Epub 2019 Mar 1.
Brain-derived neurotrophic factor (BDNF) gene is associated with increased risk of posttraumatic stress disorder (PTSD) and plays a role in neuroplasticity, cognition and memory. BDNF has strong potential as a therapeutic target as studies have shown that antidepressants, electroconvulsive treatment and exercise modulate BDNF expression and methylation. In this study we examined the role of BDNF methylation and expression in PTSD and the implications of exercise in mediating these effects. BDNF DNA methylation and gene expression analysis was performed in a sample of 96 male Vietnam veterans. Cases were combat-exposed veterans with current PTSD (n = 48) and controls were combat exposed veterans with no past or current PTSD diagnosis (n = 48). No association between BDNF mRNA and PTSD was identified. PTSD was associated with decreased methylation at three BDNF CpG sites (cg01546433 P = 0.004835; cg24650785 P = 0.000259 and cg002298481 P = 0.000672). Differential BDNF methylation was associated with exercise, with active exercise associated with lower methylation levels at three CpG sites (cg04481212 P = 0.005; cg01546433 P = 0.025 and cg00298481 P = 0.035). Given that exercise mediates BDNF action on cognitive plasticity, exercise may be a non-invasive, drug free option in the treatment of PTSD.
脑源性神经营养因子（BDNF）基因与创伤后应激障碍（PTSD）风险增加有关，在神经可塑性、认知和记忆中发挥作用。BDNF 作为一种治疗靶点具有很大的潜力，因为研究表明抗抑郁药、电惊厥治疗和运动可以调节 BDNF 的表达和甲基化。在这项研究中，我们研究了 BDNF 甲基化和表达在 PTSD 中的作用，以及运动在介导这些效应中的作用。对 96 名越南男性退伍军人样本进行了 BDNF 甲基化和基因表达分析。病例组为有 PTSD 的暴露于战斗的退伍军人（n=48），对照组为无 PTSD 既往或现病史的暴露于战斗的退伍军人（n=48）。BDNF mRNA 与 PTSD 之间没有关联。PTSD 与三个 BDNF CpG 位点的甲基化减少有关（cg01546433，P=0.004835；cg24650785，P=0.000259 和 cg002298481，P=0.000672）。BDNF 甲基化的差异与运动有关，积极运动与三个 CpG 位点的低甲基化水平有关（cg04481212，P=0.005；cg01546433，P=0.025 和 cg00298481，P=0.035）。鉴于运动调节 BDNF 对认知可塑性的作用，运动可能是治疗 PTSD 的一种非侵入性、无药物选择。
