Tammi M, Seppälä P O, Lehtonen A, Möttönen M
Atherosclerosis. 1978 Feb;29(2):191-4. doi: 10.1016/0021-9150(78)90007-2.
Human coronary arteries with various degrees of atherosclerosis were analyzed for the concentration of different types of glycosaminoglycans (GAGs). The changes in GAGs were considered against the background of macroscopic atherosclerosis, and the concentration of glycoprotein-bound hexosamines, collagen, calcium and cholesterol. The concentration of calcium was increased and that of hyaluronic acid decreased even in mildly atherosclerotic coronary arteries. The additional changes in advanced atherosclerosis included the increase of collagen and dermatan sulphate and the decrease of heparan sulphate. Cholesterol was increased in mild, and even further in advanced, atheroslcerosis. The concentrations of chondroitin sulphates and glycoprotein-bound hexosamines were not significantly affected by atherosclerosis.
对具有不同程度动脉粥样硬化的人体冠状动脉进行分析，以测定不同类型糖胺聚糖（GAGs）的浓度。结合糖蛋白的己糖胺、胶原蛋白、钙和胆固醇的浓度情况，在宏观动脉粥样硬化的背景下考量GAGs的变化。即使在轻度动脉粥样硬化的冠状动脉中，钙浓度也升高，而透明质酸浓度降低。动脉粥样硬化进展期的其他变化包括胶原蛋白和硫酸皮肤素增加，硫酸乙酰肝素减少。胆固醇在轻度动脉粥样硬化时升高，在动脉粥样硬化进展期进一步升高。硫酸软骨素和结合糖蛋白的己糖胺浓度未受动脉粥样硬化的显著影响。
