Rose H D
Am J Med Sci. 1978 May-Jun;275(3):265-9. doi: 10.1097/00000441-197805000-00004.
Fifty-five patients with venous catheter-associated candidemia were seen over a 13-year period. Thirty-five patients recovered from the infection. Twenty-six of these patients became afebrile within 72 hours of catheter removal; none were treated with systemic antifungal agents. Endophthalmitis appeared in four patients, three of whom had significant loss of vision. Nine patients had persistent candidemia following catheter removal and required antifungal therapy; none developed metastatic infection. Twenty other critically ill patients died during fungemia. Two of these patients were found to have Candida endocarditis that arose from previous catheter infections not suspected of being caused by this organism. Prevention of candidemia by proper care of indwelling vascular catheters is the ultimate goal. Appropriate management of the episodes of candidemia that occur may avert serious metastatic complications.
在13年的时间里，共观察到55例静脉导管相关念珠菌血症患者。35例患者感染痊愈。其中26例患者在拔除导管后72小时内退热；均未接受全身性抗真菌药物治疗。4例患者发生眼内炎，其中3例视力严重丧失。9例患者在拔除导管后仍有持续性念珠菌血症，需要抗真菌治疗；均未发生转移性感染。另外20例重症患者在真菌血症期间死亡。其中2例患者被发现患有念珠菌性心内膜炎，其源于先前未怀疑由该病原体引起的导管感染。通过妥善护理留置血管导管预防念珠菌血症是最终目标。对发生的念珠菌血症发作进行适当管理可能避免严重的转移性并发症。
