新生儿血红蛋白和血细胞比容水平的参考范围与胎龄（22⁻42周）和出生后年龄（0⁻29天）的关系：数学建模
Reference Ranges for Hemoglobin and Hematocrit Levels in Neonates as a Function of Gestational Age (22⁻42 Weeks) and Postnatal Age (0⁻29 Days): Mathematical Modeling.
作者信息
Scholkmann Felix, Ostojic Daniel, Isler Helene, Bassler Dirk, Wolf Martin, Karen Tanja
机构信息
Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
出版信息
Children (Basel). 2019 Mar 1;6(3):38. doi: 10.3390/children6030038.
Hematological values of neonates need to be interpreted taking into account the fact that the reference ranges depend on the age of the neonate. We aimed to derive two general mathematical models for reference ranges for hemoglobin concentration (cHb) and hematocrit (Hct) levels in neonates as a function of gestational age (GA) and postnatal age (PNA), since it is known that GA and PNA are independent factors determining cHb and Hct. For this purpose, cHb and Hct values from the data set of Henry and Christensen (2015, ., 42, 483⁻497) from about 100,000 neonates (GA: 22⁻42 weeks, PNA: 0⁻28 days) were used and general models with two quadratic functions were derived. To the best of our knowledge, the models we have developed are the first published ones to provide reference ranges for cHb and Hct for neonates incorporating the parallel dependence on GA and PNA.
新生儿的血液学指标需要结合参考范围取决于新生儿年龄这一事实来解读。我们旨在推导两个通用数学模型，以得出新生儿血红蛋白浓度（cHb）和血细胞比容（Hct）水平的参考范围，该范围是胎龄（GA）和出生后年龄（PNA）的函数，因为已知GA和PNA是决定cHb和Hct的独立因素。为此，我们使用了Henry和Christensen（2015年，……，42，483⁻497）数据集中约100,000名新生儿（GA：22⁻42周，PNA：0⁻28天）的cHb和Hct值，并推导了具有两个二次函数的通用模型。据我们所知，我们开发的模型是首个发表的，能为新生儿cHb和Hct提供参考范围的模型，该模型纳入了对GA和PNA的并行依赖性。
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