Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Department of Microbiology and Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan.
Cells. 2019 Mar 2;8(3):212. doi: 10.3390/cells8030212.
The evidence of association between sexually transmitted infection and prostatic inflammation in human prostate cancer (PCa) is limited. Here, we sought to examine the potential association of prostatic infection with the inflammatory environment and prostate carcinogenesis. We screened surgical and biopsy specimens from 45 patients with PCa against a panel of sexually transmitted infection-related organisms using polymerase chain reaction and examined the severity of intraprostatic inflammation by pathologic examination. Among tested organisms, the rate of (Mg) infection was significantly different between the prostate cancer cohort and benign prostate hyperplasia (BPH) cohort ( = 0.03). Mg infection in the surgical specimens was associated with younger patients. The rate of extensive disease (pT2c⁻3b) was higher in Mg-positive patients than in Mg-negative patients ( = 0.027). No significant correlation was observed between Mg infection status and the grade of intraprostatic inflammation. The detection sensitivity of biopsy specimens was 61% for Mg and 60% for human papillomavirus (HPV)18, indicating possible clinical application of this material. A comprehensive understanding of the correlation between the urogenital microbiome and inflammation would facilitate the development of strategies for PCa prevention. Further studies are required to explore its clinical utility in recommendations of early re-biopsy, close follow-up, and treatment by antibiotics.
性传播感染与人类前列腺癌（PCa）前列腺炎症之间的关联证据有限。在这里，我们试图研究前列腺感染与炎症环境和前列腺癌发生之间的潜在关联。我们使用聚合酶链反应（PCR）对 45 名 PCa 患者的手术和活检标本进行了一组与性传播感染相关的病原体检测，并通过病理检查检查了前列腺内炎症的严重程度。在测试的病原体中，（Mg）感染的比率在前列腺癌组和良性前列腺增生（BPH）组之间存在显著差异（= 0.03）。手术标本中 Mg 感染与年轻患者有关。Mg 阳性患者的广泛疾病（pT2c⁻3b）发生率高于 Mg 阴性患者（= 0.027）。Mg 感染状态与前列腺内炎症程度之间没有观察到显著相关性。活检标本的检测灵敏度为 Mg 阳性 61%，HPV18 阳性 60%，表明该材料可能具有临床应用价值。全面了解泌尿生殖微生物组与炎症之间的相关性将有助于制定 PCa 预防策略。需要进一步研究来探索其在建议早期再次活检、密切随访和抗生素治疗方面的临床应用价值。
