Laboratory of Pharmaceutical Nanomaterials Science, Department of Materials Science and Engineering, Technion-Israel Institute of Technology, 320003 Haifa, Israel.
Institute of Macromolecular Chemistry, Czech Academy of Sciences, Heyrovského náměstí 2, 162 06 Prague 6, Czechia; Department of Analytical Chemistry, Charles University, Faculty of Science, Hlavova 8, 128 43 Prague 2, Czechia.
Carbohydr Polym. 2019 May 15;212:412-420. doi: 10.1016/j.carbpol.2019.02.022. Epub 2019 Feb 16.
In this work, we synthesized and characterized the self-assembly behavior of a chitosan-poly(methyl methacrylate) graft copolymer and the properties of the formed nanoparticles by static and dynamic light scattering, small-angle neutron scattering, and transmission electron microscopy. Overall, our results indicate that the hydrophobization of the chitosan side-chain with PMMA leads to a complex array of small unimolecular and/or small-aggregation number "building blocks" that further self-assemble into larger amphiphilic nanoparticles.
在这项工作中，我们通过静态和动态光散射、小角中子散射和透射电子显微镜合成并表征了壳聚糖-聚甲基丙烯酸甲酯接枝共聚物的自组装行为以及形成的纳米粒子的性质。总的来说，我们的结果表明，壳聚糖侧链的疏水化与 PMMA 导致了复杂的小分子单分子和/或小聚集数“构建块”的排列，这些“构建块”进一步自组装成更大的两亲性纳米粒子。
