Institute of Innate Immunity, University of Bonn, Sigmund-Freud-Strasse 25, 53127 Bonn, Germany.
Medizinische Klinik und Poliklinik 3, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, Munich 81675, Germany.
Hematol Oncol Clin North Am. 2019 Apr;33(2):215-231. doi: 10.1016/j.hoc.2018.12.002. Epub 2019 Jan 9.
The innate immune system has evolved as a first line of defense against invading pathogens and acts via classes of germline-encoded receptor systems to respond with proinflammatory cytokines. Innate immune cells, predominantly cells of the myeloid compartment, are capable of providing a potent basis for boosting adaptive immunity in malignant diseases. The authors review their current understanding of the molecular mechanisms whereby innate pattern recognition receptors participate in immunosurveillance of cancer cells. They discuss how innate effector mechanisms are currently being targeted pharmacologically and how improved understanding of the biology of these pathways is leading to novel immunotherapies of cancer.
天然免疫系统作为抵御入侵病原体的第一道防线而进化，通过胚系编码受体系统的类别来发挥作用，以产生促炎细胞因子。天然免疫细胞，主要是髓系细胞，能够为增强恶性疾病中的适应性免疫提供有力基础。作者回顾了他们目前对天然模式识别受体参与癌细胞免疫监视的分子机制的理解。他们讨论了目前如何通过药理学靶向天然效应机制，以及对这些途径的生物学的更好理解如何导致癌症的新免疫疗法。
