Li Ming O, Zhang Jing, Xu Zijian, Zhang Xian, Li Peng, Cornish Andrew E
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; email:
Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Annu Rev Immunol. 2024 Jun;42(1):647-677. doi: 10.1146/annurev-immunol-083122-043836. Epub 2024 Jun 14.
Lymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to surveil epithelial cell transformation and carcinoma development, as well as cancer cell metastasis at selected distant organs, and thus represents a primordial cancer immune defense module. Here we review how distinct lineages of tissue-resident innate lymphoid cells, innate-like T cells, and adaptive T cells participate in a form of multilayered cancer immunity in murine models and patients, and how their convergent effector programs may be targeted through both shared and private regulatory pathways for cancer immunotherapy.
跨越整个先天-适应性谱系的淋巴细胞能够稳定地驻留在组织中，并构成针对免疫挑战的局部防御网络的一个组成部分。在与上皮细胞和内皮细胞的紧密相互作用中，组织驻留淋巴细胞感知由感染性微生物和屏障部位的非生物应激引发的抗原和警报素，并产生效应反应以恢复组织稳态。值得注意的是，最近已证明这种宿主细胞导向的免疫防御系统可监测上皮细胞转化和癌发展，以及选定远处器官的癌细胞转移，因此代表了一种原始的癌症免疫防御模块。在这里，我们综述了组织驻留先天淋巴细胞、先天样T细胞和适应性T细胞的不同谱系如何在小鼠模型和患者中参与一种多层癌症免疫形式，以及它们趋同的效应程序如何通过共享和特定的调节途径被靶向用于癌症免疫治疗。
