Li Qiumei, Tian Shuoran, Liang Jiadi, Fan Jiqiang, Lai Junzhong, Chen Qi
Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Fujian Normal University, Fuzhou, China.
The Cancer Center, Union Hospital, Fujian Medical University, Fuzhou, China.
Front Pharmacol. 2021 Nov 15;12:779425. doi: 10.3389/fphar.2021.779425. eCollection 2021.
DNA immune recognition regulation mediated by the cGAS-STING pathway plays an important role in immune functions. Under normal physiological conditions, cGAS can recognize and bind to invading pathogen DNA and activate the innate immune response. On the other hand, abnormal activation of cGAS or STING is closely related to autoimmune diseases. In addition, activation of STING proteins as a bridge connecting innate immunity and adaptive immunity can effectively restrain tumor growth. Therefore, targeting the cGAS-STING pathway can alleviate autoimmune symptoms and be a potential drug target for treating cancer. This article summarizes the current progress on cGAS-STING pathway modulators and lays the foundation for further investigating therapeutic development in autoimmune diseases and tumors.
由cGAS-STING通路介导的DNA免疫识别调节在免疫功能中发挥着重要作用。在正常生理条件下，cGAS能够识别并结合入侵病原体的DNA，激活先天免疫反应。另一方面，cGAS或STING的异常激活与自身免疫性疾病密切相关。此外，作为连接先天免疫和适应性免疫桥梁的STING蛋白的激活能够有效抑制肿瘤生长。因此，靶向cGAS-STING通路可以缓解自身免疫症状，成为治疗癌症的潜在药物靶点。本文总结了cGAS-STING通路调节剂的当前研究进展，为进一步研究自身免疫性疾病和肿瘤的治疗发展奠定了基础。
