Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain; Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain; Department of Psychiatry, Getafe University Hospital, Madrid, Spain.
Laboratory of Neurobiology and Experimental Neurology, Department of Physiology, Faculty of Medicine, University of La Laguna, Tenerife, Canary Islands, Spain; Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.
Parkinsonism Relat Disord. 2019 Jun;63:100-105. doi: 10.1016/j.parkreldis.2019.02.031. Epub 2019 Feb 27.
Current basal ganglia models integrate information obtained from humans and animals to explain motor disorders in Parkinson's disease. These models explain some motor disturbances of Parkinson's disease (PD), but different clinical observations which remain unexplained have promoted the development of new basal ganglia (BG) models. The present study uses the time-relationship (partial correlation) of the BOLD-signal fluctuations to study the influence of PD on BG interactions of 17 age-matched controls (58.7 ± 5.3 years of age) and 24 PD patients (56.7 ± 8.4 years of age). Controls showed a complex functional connectivity of BG with a positive correlation between some nuclei (synchrony) and a negative correlation between other nuclei (anti-synchrony). This functional connectivity was different in PD-patients who showed: 1. an increased synchrony between the primary motor cortex(M1)-external pallidum(GPe), putamen(Put)-GPe, Put-subthalamic nucleus (STN), STN-internal pallidum (GPi), STN-motor thalamus (Tal), STN-GPi substantia nigra (SN) and SN-Tal, 2. a decreased synchrony between Put-GPi, GPe-STN, GPe-SN, STN-SN and GPi-SN, and 3. an increased anti-synchrony between GPe-SN and GPi-Tal. In control subjects, the motor-task increased the Put-Tal, GPi-SN and STN-Tal synchrony, decreased the STN-GPi and STN-SN synchrony and decreased the M1-GPe and the GPe-GPi anti-synchrony. The effect of the motor-task was very different in PD-patients, in whom it induced a decrease of the M1-GPe, STN-GPi and SN-Tal synchrony and a decrease of the GPe-Tal and GPe-SN anti-synchrony. Functional connectivity imaging methods may provide data that cannot be obtained by other methods in humans, and that may help to understand the physiology of BG and its deterioration in PD.
当前的基底神经节模型整合了来自人类和动物的信息，以解释帕金森病的运动障碍。这些模型解释了帕金森病（PD）的一些运动障碍，但不同的临床观察结果仍未得到解释，这促进了新的基底神经节（BG）模型的发展。本研究使用 BOLD 信号波动的时间关系（偏相关）来研究 PD 对 17 名年龄匹配的对照组（58.7±5.3 岁）和 24 名 PD 患者（56.7±8.4 岁）BG 相互作用的影响。对照组显示出 BG 的复杂功能连接，一些核之间存在正相关（同步），而其他核之间存在负相关（反同步）。这种功能连接在 PD 患者中有所不同，他们表现出：1. 初级运动皮层（M1）-外苍白球（GPe）、壳核（Put）-GPe、Put-丘脑底核（STN）、STN-内苍白球（GPi）、STN-运动丘脑（Tal）、STN-GPi 黑质（SN）和 SN-Tal 之间的同步性增加；2. Put-GPi、GPe-STN、GPe-SN、STN-SN 和 GPi-SN 之间的同步性降低；3. GPe-SN 和 GPi-Tal 之间的反同步性增加。在对照组中，运动任务增加了 Put-Tal、GPi-SN 和 STN-Tal 的同步性，降低了 STN-GPi 和 STN-SN 的同步性，降低了 M1-GPe 和 GPe-GPi 的反同步性。运动任务对 PD 患者的影响非常不同，它导致 M1-GPe、STN-GPi 和 SN-Tal 的同步性降低，以及 GPe-Tal 和 GPe-SN 的反同步性降低。功能连接成像方法可以提供人类其他方法无法获得的数据，这些数据可能有助于理解基底神经节的生理学及其在 PD 中的恶化。
