揭示中期染色体中的染色质组织。
Revealing chromatin organization in metaphase chromosomes.
机构信息
École Polytechnique Fédérale de Lausanne, SB ISIC LCBM, Lausanne, Switzerland.
出版信息
EMBO J. 2019 Apr 1;38(7). doi: 10.15252/embj.2019101699. Epub 2019 Mar 4.
Abstract
The local structural organization of chromatin in mitotic chromosomes is not well understood. A new cryo‐electron tomography study from the Daban laboratory (Chicano , 2019) reveals that mitotic chromatin isolated from human cells can assume a plate‐like fine structure, containing layers of interdigitated nucleosomes. Such a multilayered organization suggests a possible model for mitotic chromatin compaction.
摘要
有丝分裂染色体中染色质的局部结构组织尚不清楚。Daban 实验室的一项新的冷冻电子断层扫描研究（Chicano，2019）表明，从人细胞中分离的有丝分裂染色质可以呈现出板状的精细结构，包含交错的核小体层。这种多层组织为有丝分裂染色质的压缩提供了一个可能的模型。
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