Dermendzhiev Svetlan, Petrova Atanaska, Dermendzhiev Tihomir
Department of Occupational Diseases and Toxicology, Second Department of Internal Medicine, Faculty of Medicine, Medical University-Plovdiv, Plovdiv, Bulgaria.
Department of Occupational Diseases and Allergology, University Hospital "St. George"-Plovdiv, Plovdiv, Bulgaria.
Open Access Maced J Med Sci. 2019 Feb 13;7(3):369-372. doi: 10.3889/oamjms.2019.121. eCollection 2019 Feb 15.
Angioneurotic oedema (AE) is an unpredictable and dangerous disease directly threatening the patient's life due to a sudden onset of upper respiratory tract obstruction. The disease is associated with various causes and triggering factors, but little is known about the conditions that accompany AE.
The study aims to determine the age-specificities and the spectrum of concomitant diseases in patients with AE.
The subjects of observation were 88 patients (53 women and 35 men) with angioneurotic oedema who underwent diagnostics and treatment in the Department of Occupational Diseases and Clinical Allergology of University hospital "Saint George"-Plovdiv.
The highest level of disease prevalence was found in the age group over 50 years, both in males (45.71%) and females (54.72%). We found that the most often concomitant diseases in our patients with AE are cardiovascular (33%). On second place are the patients with other accompanying conditions outside of the target groups (27.3%). Patients with AE and autoimmune thyroiditis were 14.8%, and those with AE and skeletal-muscle disorders-10.2%. Given the role of hereditary factors in this disease, the profession of the patients is considered insignificant.
Angioedema occurs in all age groups, but half of the cases are in people over 50 years of age. The most common concomitant diseases in angioedema are cardiovascular diseases.
血管性水肿（AE）是一种不可预测且危险的疾病，由于上呼吸道梗阻突然发作，直接威胁患者生命。该疾病与多种病因和触发因素相关，但对伴随AE出现的情况了解甚少。
本研究旨在确定AE患者的年龄特异性及伴随疾病谱。
观察对象为88例血管性水肿患者（53例女性和35例男性），他们在普罗夫迪夫“圣乔治”大学医院职业病与临床过敏科接受诊断和治疗。
50岁以上年龄组的疾病患病率最高，男性为45.71%，女性为54.72%。我们发现，AE患者中最常伴随的疾病是心血管疾病（33%）。其次是目标组以外伴有其他情况的患者（27.3%）。患有AE和自身免疫性甲状腺炎的患者占14.8%，患有AE和骨骼肌疾病的患者占10.2%。考虑到遗传因素在该疾病中的作用，患者的职业被认为无关紧要。
血管性水肿在所有年龄组均有发生，但半数病例发生在50岁以上人群中。血管性水肿最常见的伴随疾病是心血管疾病。
